ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2012
Protective effects of isothiocyanates on blood-CSF barrier disruption induced by oxidative stress.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Beyond the Tongue: Brassica Vegetables, Distributed Taste Receptors, and Their Role in Holistic Health.Integrative medicine (Encinitas, Calif.) · 2025Article
- Growth Factors and the Choroid Plexus: Their Role in Posthemorrhagic Hydrocephalus.Biomedicines · 2025Article
- The glutathione-dependent neuroprotective activity of the blood-CSF barrier is inducible through the Nrf2 signaling pathway during postnatal development.Fluids and barriers of the CNS · 2025Article
- Review
- The HAntioxidants (Basel, Switzerland) · 2021Article
- Isothiocyanates: cholinesterase inhibiting, antioxidant, and anti-inflammatory activity.Journal of enzyme inhibition and medicinal chemistry · 2018Article
- Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis.Molecular neurobiology · 2018Review
- The Phenolic Components ofOxidative medicine and cellular longevity · 2018Article
- Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling.International journal of molecular sciences · 2017Article
- DNA Microarray Highlights Nrf2-Mediated Neuron Protection Targeted by Wasabi-Derived Isothiocyanates in IMR-32 Cells.Gene regulation and systems biology · 2016Article
- Article
- Efflux transporters in blood-brain interfaces of the developing brain.Frontiers in neuroscience · 2015Review
- Conditioned media of choroid plexus epithelial cells induces Nrf2-activated phase II antioxidant response proteins and suppresses oxidative stress-induced apoptosis in PC12 cells.Journal of molecular neuroscience : MN · 2014Article
- Stress-induced stimulation of choline transport in cultured choroid plexus epithelium exposed to low concentrations of cadmium.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Cellular polarity in aging: role of redox regulation and nutrition.Genes & nutrition · 2014Article
- Activating the Nrf2-mediated antioxidant response element restores barrier function in the alveolar epithelium of HIV-1 transgenic rats.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Expression of the Nrf2-system at the blood-CSF barrier is modulated by neonatal inflammation and hypoxia-ischemia.Journal of inherited metabolic disease · 2013Article
- Sulforaphane as a potential protective phytochemical against neurodegenerative diseases.Oxidative medicine and cellular longevity · 2013Review
- Dimethyl fumarate modulation of immune and antioxidant responses: application to HIV therapy.Critical reviews in immunology · 2013Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The choroid plexuses (CPs) form the blood-cerebrospinal fluid (CSF) barrier (BCSFB) and play an important role in maintaining brain normal function and the brain response to injury. Many neurological disorders are associated with oxidative stress that can impact CP function. This study examined the effects of isothiocyanates, an abundant component in cruciferous vegetables, on H(2)O(2)-induced BCSFB disruption and CP cell death in vitro. It further examined the potential role of a transcription factor, nuclear factor erythroid 2-related factor 2 (Nrf2), in isothiocyanate-induced protection. Sulforaphane (SF) significantly reduced H(2)O(2)-induced BCSFB disruption as assessed by transepithelial electrical resistance (29 ± 7% reduction vs. 92 ± 2% decrease in controls) and [(3)H]mannitol permeability. Allyl-isothiocyanate (AITC) had a similar protective effect. H(2)O(2)-induced epithelial cell death was also reduced by these isothiocyanates. In primary CP cells, SF and AITC reduced cell death by 42 ± 3% and 53 ± 10%, respectively. Similar protection was found in a CP cell line Z310. Protection was only found with pretreatment for 12-48 h and not with acute exposure (1 h). The protective effects of SF and AITC were associated with Nrf2 nuclear translocation and upregulated expression of antioxidative systems regulated by Nrf2, including heme oxygenase-1, NAD(P)H quinine oxidoreductase, and cysteine/glutamate exchange transporter. Thus isothiocyanates, as diet or medicine, may be a method for protecting BCSFB in neurological disorders.
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Registered trials
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