ArticleBiology of reproduction2012
Peripubertal vitamin D(3) deficiency delays puberty and disrupts the estrous cycle in adult female mice.
Article in Biology of reproduction, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 92 citations in OpenAlex.
- A systematic review and meta-analysis of the association between vitamin D and ovarian reserve.Scientific reports · 2021Pooled it
- The Investigation of Vitamin D and Menstrual Cycles Trial (the inVitD Trial): A clinical trial of vitamin D supplementation on the hypothalamic-pituitary-ovarian axis.Contemporary clinical trials · 2026Article
- Vitamin D levels and prolonged menstrual cycle in women with polycystic ovary syndrome: a cross-sectional study.Frontiers in nutrition · 2026Article
- Supplementing 25-Hydroxy-Vitamin DAnimals : an open access journal from MDPI · 2025Article
- Ambient air pollution in critical windows of exposure and spontaneous miscarriage in a preconception cohort.Environmental research · 2025Article
- Consequences of vitamin D deficiency or overdosage on follicular development and steroidogenesis in Normo and hypo calcemic mouse models.Scientific reports · 2025Article
- Article
- Effects of 25-hydroxycholecalciferol supplementation during gestation on sow performance, offspring development, and intestinal microbiota in sows and piglets.Journal of animal science · 2025Article
- The role of vitamin D3 in follicle development.Journal of ovarian research · 2024Review
- Association between 25-hydroxyvitamin D concentrations and pubertal timing: 6-14-year-old children and adolescents in the NHANES 2015-2016.Frontiers in endocrinology · 2024Article
- Interaction between Vitamin D homeostasis, gut microbiota, and central precocious puberty.Frontiers in endocrinology · 2024Review
- Association between Vitamin D Levels, Puberty Timing, and Age at Menarche.Children (Basel, Switzerland) · 2023Review
- Decreased growth differentiation factor 9, bone morphogenetic protein 15, and forkhead box O3a expressions in the ovary via ulipristal acetate.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Age-related changes in Folliculogenesis and potential modifiers to improve fertility outcomes - A narrative review.Reproductive biology and endocrinology : RB&E · 2022Review
- Vitamin D status and parathyroid hormone assessment in girls with central precocious puberty.Journal of endocrinological investigation · 2022Article
- Changes in the expressions of annexin A1, annexin A5, inhibin/activin subunits, and vitamin D receptor mRNAs in pituitary glands of female rats during the estrous cycle: correlation analyses among these factors.The Journal of veterinary medical science · 2022Article
- Impact of Dietary Advanced Glycation End Products on Female Reproduction: Review of Potential Mechanistic Pathways.Nutrients · 2022Review
- Effects of supraphysiological vitamin DHistochemistry and cell biology · 2021Article
- Vitamin D in follicular development and oocyte maturation.Reproduction (Cambridge, England) · 2021Review
- Perinatal exposure to high dietary advanced glycation end products affects the reproductive system in female offspring in mice.Molecular human reproduction · 2020Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The mechanism(s) by which vitamin D(3) regulates female reproduction is minimally understood. We tested the hypothesis that peripubertal vitamin D(3) deficiency disrupts hypothalamic-pituitary-ovarian physiology. To test this hypothesis, we used wild-type mice and Cyp27b1 (the rate-limiting enzyme in the synthesis of 1,25-dihydroxyvitamin D(3)) null mice to study the effect of vitamin D(3) deficiency on puberty and reproductive physiology. At the time of weaning, mice were randomized to a vitamin D(3)-replete or -deficient diet supplemented with calcium. We assessed the age of vaginal opening and first estrus (puberty markers), gonadotropin levels, ovarian histology, ovarian responsiveness to exogenous gonadotropins, and estrous cyclicity. Peripubertal vitamin D(3) deficiency significantly delayed vaginal opening without affecting the number of GnRH-immunopositive neurons or estradiol-negative feedback on gonadotropin levels during diestrus. Young adult females maintained on a vitamin D(3)-deficient diet after puberty had arrested follicular development and prolonged estrous cycles characterized by extended periods of diestrus. Ovaries of vitamin D(3)-deficient Cyp27b1 null mice responded to exogenous gonadotropins and deposited significantly more oocytes into the oviducts than mice maintained on a vitamin D(3)-replete diet. Estrous cycles were restored when vitamin D(3)-deficient Cyp27b1 null young adult females were transferred to a vitamin D(3)-replete diet. This study is the first to demonstrate that peripubertal vitamin D(3) sufficiency is important for an appropriately timed pubertal transition and maintenance of normal female reproductive physiology. These data suggest vitamin D(3) is a key regulator of neuroendocrine and ovarian physiology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.