ArticleEuropean radiology2012
Association between carotid plaque enhancement shown by multidetector CT angiography and histologically validated microvessel density.
Article in European radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology.AJNR. American journal of neuroradiology · 2018Guideline
- Correlation between fissured fibrous cap and contrast enhancement: preliminary results with the use of CTA and histologic validation.AJNR. American journal of neuroradiology · 2014Trial
- Evaluation of Carotid Plaque Vulnerability Using Dual-energy Computed Tomography Angiography: a Prospective Observational Study.Clinical neuroradiology · 2026Observational
- Dual-energy computed tomography iodine maps for visualizing enhancement and estimating characteristics in plaques.Radiology case reports · 2026Article
- Assessment of perivascular adipose tissue attenuation using dual-layer spectral-detector CTA for identification of symptomatic carotid plaques.Japanese journal of radiology · 2025Article
- Acute stroke risk prediction model based on dual-energy CTA-derived carotid plaque, perivascular adipose tissue characteristics, and serum lipid parameters: a dual-center study.Neuroradiology · 2025Article
- Association between pericarotid fat attenuation index and clinical outcomes of symptomatic cerebral small vessel disease.Quantitative imaging in medicine and surgery · 2025Article
- The value of contrast-enhanced ultrasound in assessing carotid plaque vulnerability and predicting stroke risk.Scientific reports · 2025Article
- Development of a nomogram model for predicting acute stroke events based on dual-energy CTA analysis of carotid intraplaque and perivascular adipose tissue.Frontiers in neurology · 2025Article
- Embolic strokes of undetermined source: a clinical consensus statement of the ESC Council on Stroke, the European Association of Cardiovascular Imaging and the European Heart Rhythm Association of the ESC.European heart journal · 2024Article
- A new predictor of coronary artery disease in acute ischemic stroke or transient ischemic attack patients: pericarotid fat density.European radiology · 2024Article
- Identification of vulnerable carotid plaque with histologically validated CT-derived plaque maps.The British journal of radiology · 2023Article
- Impact Analysis of Different CT Configurations of Carotid Artery Plaque Calcifications on Cerebrovascular Events.AJNR. American journal of neuroradiology · 2022Article
- Review of imaging biomarkers for the vulnerable carotid plaque.JVS-vascular science · 2021Review
- CT imaging features of carotid artery plaque vulnerability.Annals of translational medicine · 2020Review
- Advanced imaging in the diagnosis of cardiovascular diseases: the "ongoing" future.Cardiovascular diagnosis and therapy · 2020Article
- Carotid plaque imaging profiling in subjects with risk factors (diabetes and hypertension).Cardiovascular diagnosis and therapy · 2020Review
- Plaque imaging volume analysis: technique and application.Cardiovascular diagnosis and therapy · 2020Review
- Carotid plaque imaging and the risk of atherosclerotic cardiovascular disease.Cardiovascular diagnosis and therapy · 2020Review
- Insight from imaging on plaque vulnerability: similarities and differences between coronary and carotid arteries-implications for systemic therapies.Cardiovascular diagnosis and therapy · 2020Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCarotid plaques analysed by MDCTA can show contrast enhancement. The purpose of this study was to explore the association between carotid plaque enhancement (CPE) and microvessel density. MATERIALS AND
methodsWe obtained IRB approval. Twenty-nine consecutive (male, 20; median age, 63) symptomatic patients studied with 16-detector CT were prospectively analysed. Examinations were performed before and after intravenous contrast medium administration, and analysis of plaque enhancement was performed. Patients underwent "en bloc" carotid endarterectomy; histological sections were prepared and the presence of microvessels quantified. Logistic regression analysis as well as ROC curve and area under the curve was calculated.
resultsA statistically significant association between the degree of CPE and microvessel density (P = 0.009; rho = 0.553) was observed. The ROC curve analysis confirmed this association with an area under the curve of 0.906, 0.735, 0.644 and 0.546 for CPE of 10 HU, 15 HU, 20 HU and 25 HU respectively. There was a statistically significant difference between the CPE and the degree of neovascularisation (P = 0.0003).
conclusionResults of this preliminary study suggest that CPE might be associated with the microvessel density. Histological analysis seems to demonstrate that the degree of intra-plaque neo-vascularisation is statistically associated with CPE. KEY POINTS: Carotid artery plaque enhancement at CT is associated with microvessel density. The degree of intra-plaque neo-vascularisation is statistically associated with carotid plaque enhancement. Plaque enhancement at CT should be considered when assessing vulnerable plaques.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.