ArticleJournal of neurophysiology2012
Complex autonomous firing patterns of striatal low-threshold spike interneurons.
Article in Journal of neurophysiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 79 citations in OpenAlex.
- Thermally induced neuronal plasticity in the hypothalamus mediates heat tolerance.Nature neuroscience · 2025Article
- A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Acetylcholine waves and dopamine release in the striatum.Nature communications · 2023Article
- Role of upregulation of the KAging cell · 2022Article
- Striatal low-threshold spiking interneurons locally gate dopamine.Current biology : CB · 2021Article
- A dynamical model for the basal ganglia-thalamo-cortical oscillatory activity and its implications in Parkinson's disease.Cognitive neurodynamics · 2021Article
- Er81 Transcription Factor Fine-Tunes Striatal Cholinergic Interneuron Activity and Drives Habit Formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Axonal Modulation of Striatal Dopamine Release by Local γ-Aminobutyric Acid (GABA) Signalling.Cells · 2021Review
- Fast spiking interneuron activity in primate striatum tracks learning of attention cues.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities.Cell reports · 2020Article
- Broadband Entrainment of Striatal Low-Threshold Spike Interneurons.Frontiers in neural circuits · 2020Article
- Thinking Outside the Box (and Arrow): Current Themes in Striatal Dysfunction in Movement Disorders.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2019Review
- Excitatory extrinsic afferents to striatal interneurons and interactions with striatal microcircuitry.The European journal of neuroscience · 2019Review
- Cholinergic modulation of striatal microcircuits.The European journal of neuroscience · 2019Review
- Inhibition of Nigrostriatal Dopamine Release by Striatal GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Hippocampal-Evoked Feedforward Inhibition in the Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Identification and Characterization of a Novel Spontaneously Active Bursty GABAergic Interneuron in the Mouse Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Heterogeneity and Diversity of Striatal GABAergic Interneurons: Update 2018.Frontiers in neuroanatomy · 2018Article
- Dichotomous Effects of Mu Opioid Receptor Activation on Striatal Low-Threshold Spike Interneurons.Frontiers in cellular neuroscience · 2017Article
- Differences between Dorsal and Ventral Striatum in the Sensitivity of Tonically Active Neurons to Rewarding Events.Frontiers in systems neuroscience · 2017Article
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4 authors at 2 institutions in 1 country.
Funding
Abstract
During sensorimotor learning, tonically active neurons (TANs) in the striatum acquire bursts and pauses in their firing based on the salience of the stimulus. Striatal cholinergic interneurons display tonic intrinsic firing, even in the absence of synaptic input, that resembles TAN activity seen in vivo. However, whether there are other striatal neurons among the group identified as TANs is unknown. We used transgenic mice expressing green fluorescent protein under control of neuronal nitric oxide synthase or neuropeptide-Y promoters to aid in identifying low-threshold spike (LTS) interneurons in brain slices. We found that these neurons exhibit autonomous firing consisting of spontaneous transitions between regular, irregular, and burst firing, similar to cholinergic interneurons. As in cholinergic interneurons, these firing patterns arise from interactions between multiple intrinsic oscillatory mechanisms, but the mechanisms responsible differ. Both neurons maintain tonic firing because of persistent sodium currents, but the mechanisms of the subthreshold oscillations responsible for irregular firing are different. In LTS interneurons they rely on depolarization-activated noninactivating calcium currents, whereas those in cholinergic interneurons arise from a hyperpolarization-activated potassium conductance. Sustained membrane hyperpolarizations induce a bursting pattern in LTS interneurons, probably by recruiting a low-threshold, inactivating calcium conductance and by moving the membrane potential out of the activation range of the oscillatory mechanisms responsible for single spiking, in contrast to the bursting driven by noninactivating currents in cholinergic interneurons. The complex intrinsic firing patterns of LTS interneurons may subserve differential release of classic and peptide neurotransmitters as well as nitric oxide.
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