Evidence map›Paper›PMID 22572886›Full record

ReviewSeminars in immunopathology2012

Two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases.

Motohiro Kobayashi, Hitomi Hoshino, Kenichi Suzawa, Yasuhiro Sakai, Jun Nakayama, Minoru Fukuda

Abstract readReview
PubMed Publisher
In one paragraph

Review in Seminars in immunopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Analysis ofThe journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Motohiro KobayashiDepartment of Molecular Pathology, Shinshu University Graduate School of Medicine, Asahi, Matsumoto, Japan.
Hitomi Hoshino
Kenichi Suzawa
Yasuhiro Sakai
Jun Nakayama
Minoru Fukuda
Shinshu University · JPCancer Research Center · US

Funding

THE A(1,3)FUCOSYLTRANSFERASE GENES AND SELECTIN LIGAND EXPRESSIONP01CA071932 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI FUKUDA, MINORU · 1996 to 2012
$15.5M
Polylactosamines in Development and CancerR01CA048737 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI FUKUDA, MINORU · 1989 to 2007
$3.1M
GLYCOPROTEINS IN DIFFERENTIATION AND ONCOGENESISR37CA033000 · NCI · BURNHAM INSTITUTE FOR MEDICAL RESEARCH · PI FUKUDA, MINORU · 1995 to 2004
$2.1M
GLYCOPROTEINS IN DIFFERENTIATION AND ONCOGENESISR01CA033000 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI FUKUDA, MINORU · 1985 to 2009
$1.8M
NCI NIH HHS CA33000NCI NIH HHS P01 CA71932NCI NIH HHS R01 CA48737
6 · The paper itself

Abstract

Under normal and pathological conditions, lymphocyte migration into the gastrointestinal mucosa to form gut-associated lymphoid tissue is mediated by the L-selectin ligand peripheral lymph node addressin and the integrin α4β7 ligand mucosal addressin cell adhesion molecule 1 (MAdCAM-1) expressed on high endothelial venules (HEVs) and HEV-like vessels. In this review, we discuss these two distinct lymphocyte homing systems involved in the pathogenesis of chronic inflammatory gastrointestinal diseases with reference to our and others' previously published works. We also describe a recently developed recombinant integrin α4β7 heterodimeric IgG chimera that can be used as an immunohistochemical reagent to stain functional MAdCAM-1.

Indexed as

Antigens, SurfaceCell Adhesion Molecule-1Cell Adhesion MoleculesCell MovementColitis, UlcerativeGastritisGastrointestinal TractHelicobacter InfectionsHelicobacter pyloriHumansImmunoglobulin GImmunoglobulinsLymphocytesLymphoma, B-Cell, Marginal ZoneMembrane ProteinsReceptors, Lymphocyte HomingAntigens, SurfaceCADM1 protein, humanCell Adhesion Molecule-1Cell Adhesion MoleculesImmunoglobulin GImmunoglobulinsL-selectin counter-receptorsMembrane ProteinsReceptors, Lymphocyte Homing

Identifiers

PMID22572886
OpenAlexW1976073564

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.