Evidence map›Paper›PMID 22572875›Full record

ReviewGut microbes

Microbial degradation of complex carbohydrates in the gut.

Harry J Flint, Karen P Scott, Sylvia H Duncan, Petra Louis, Evelyne Forano

Open access · bronzeAbstract readReview
In one paragraph

Review in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1,163 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,163citing papers in PubMed, 1 pooled it
35.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1,163 citing papers in PubMed, 1 synthesis or guideline pooled it, 2,175 citations in OpenAlex.

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  6. Bridging the gap:Gut microbes · 2026
    Review
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1,103 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Harry J FlintRowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen UK. h.flint@abdn.ac.uk
Karen P Scott
Sylvia H Duncan
Petra Louis
Evelyne Forano
University of Aberdeen · GBAberdeenshire Council · GBUnité Mixte de Recherche sur les Herbivores · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bacteria that colonize the mammalian intestine collectively possess a far larger repertoire of degradative enzymes and metabolic capabilities than their hosts. Microbial fermentation of complex non-digestible dietary carbohydrates and host-derived glycans in the human intestine has important consequences for health. Certain dominant species, notably among the Bacteroidetes, are known to possess very large numbers of genes that encode carbohydrate active enzymes and can switch readily between different energy sources in the gut depending on availability. Nevertheless, more nutritionally specialized bacteria appear to play critical roles in the community by initiating the degradation of complex substrates such as plant cell walls, starch particles and mucin. Examples are emerging from the Firmicutes, Actinobacteria and Verrucomicrobium phyla, but more information is needed on these little studied groups. The impact of dietary carbohydrates, including prebiotics, on human health requires understanding of the complex relationship between diet composition, the gut microbiota and metabolic outputs.

Indexed as

Carbohydrate MetabolismMetagenomeBacteriaCelluloseFermentationGastrointestinal TractHumansMucinsStarchCelluloseMucinsStarch

Identifiers

PMID22572875
PMCPMC3463488
OpenAlexW2114089110

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.