ArticleJournal of molecular histology2012
Autaptic muscarinic self-excitation and nitrergic self-inhibition in neurons initiating Aplysia feeding are revealed when the neurons are cultured in isolation.
Article in Journal of molecular histology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 11 citations in OpenAlex.
- Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection.Pharmacological research · 2025Article
- Sodium-mediated plateau potentials in an identified decisional neuron contribute to feeding-related motor pattern genesis inFrontiers in neural circuits · 2023Article
- Computational model of the distributed representation of operant reward memory: combinatoric engagement of intrinsic and synaptic plasticity mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Influence of Autapses on Synchronization in Neural Networks With Chemical Synapses.Frontiers in systems neuroscience · 2020Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
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Abstract
Properties of a neuron may arise via endogenous mechanisms, or via interactions with other neurons. Culturing a neuron in isolation is a useful tool to distinguish between endogenous and circuit-derived properties. We identified two remarkable functional features of pattern initiator neurons B31/B32 in Aplysia when these neurons were cultured in isolation. These features were also present in situ, but were less prominent, and would have been missed had they not been observed first in the isolated cultured neurons. The properties are likely to be present in neurons of higher animals, but have not yet been observed. One feature was autaptic muscarinic self-excitation that contributes to the neuron's plateau potential, by which it initiates behavior. The other feature was the release of nitric oxide (NO) in the absence of spiking, which causes self-inhibition at rest. The nitrergic modulation of B31/B32 is likely to contribute to the control of feeding by dietary changes in the concentration of L: -arginine, the precursor from which NO is synthesized.
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