Trial reportJournal of cognitive neuroscience2012
Dopamine agonists and the suppression of impulsive motor actions in Parkinson disease.
Trial report in Journal of cognitive neuroscience, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 77 citations in OpenAlex.
- Trial
- Neuropsychological aspects of impulse control disorders in Parkinson's disease.Frontiers in aging neuroscience · 2026Review
- Impulse Control Disorders in Parkinson's Disease: An Overview of Risk Factors, Pathogenesis and Pharmacological Management.CNS drugs · 2024Review
- The Role of a Dopamine-Dependent Limbic-Motor Network in Sensory Motor Processing in Parkinson Disease.Journal of cognitive neuroscience · 2023Article
- Combined EEG and immersive virtual reality unveil dopaminergic modulation of error monitoring in Parkinson's Disease.NPJ Parkinson's disease · 2023Article
- Huntington disease exacerbates action impulses.Frontiers in psychology · 2023Article
- Towards Conceptual Clarification of Proactive Inhibitory Control: A Review.Brain sciences · 2022Review
- Impulse control disorders in hyperprolactinemic patients on dopamine agonist therapy.Reviews in endocrine & metabolic disorders · 2022Review
- Essential tremor impairs the ability to suppress involuntary action impulses.Experimental brain research · 2022Article
- Neurophysiological Correlates of Trait Impulsivity in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2021Article
- Neuropsychiatric and Cognitive Deficits in Parkinson's Disease and Their Modeling in Rodents.Biomedicines · 2021Review
- The arrow of time: Advancing insights into action control from the arrow version of the Eriksen flanker task.Attention, perception & psychophysics · 2021Article
- Continuous force measurements reveal no inhibitory control deficits in Parkinson's disease.Experimental brain research · 2020Article
- Linking brain activity during sequential gambling to impulse control in Parkinson's disease.NeuroImage. Clinical · 2020Article
- Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson's disease.Cortex; a journal devoted to the study of the nervous system and behavior · 2019Article
- Behavioral and Neuroanatomical Account of Impulsivity in Parkinson's Disease.Frontiers in neurology · 2019Article
- Taq1A polymorphism and medication effects on inhibitory action control in Parkinson disease.Brain and behavior · 2018Article
- Action observation produces motor resonance in Parkinson's disease.Journal of neuropsychology · 2018Article
- ELF: A new measure of response capture.Psychonomic bulletin & review · 2018Review
- A model-based quantification of action control deficits in Parkinson's disease.Neuropsychologia · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The suppression of spontaneous motor impulses is an essential facet of cognitive control that is linked to frontal-BG circuitry. BG dysfunction caused by Parkinson disease (PD) disrupts the proficiency of action suppression, but how pharmacotherapy for PD impacts impulsive motor control is poorly understood. Dopamine agonists improve motor symptoms of PD but can also provoke impulsive-compulsive behaviors (ICB). We investigated whether dopamine agonist medication has a beneficial or detrimental effect on impulsive action control in 38 PD patients, half of whom had current ICB. Participants performed the Simon conflict task, which measures susceptibility to acting on spontaneous action impulses as well as the proficiency of suppressing these impulses. Compared with an off-agonist state, patients on their agonists were no more susceptible to reacting impulsively but were less proficient at suppressing the interference from the activation of impulsive actions. Importantly, agonist effects depended on baseline performance in the off-agonist state; more proficient suppressors off agonist experienced a reduction in suppression on agonist, whereas less-proficient suppressors off agonist showed improved suppression on agonist. Patients with active ICB were actually less susceptible to making fast, impulsive response errors than patients without ICB, suggesting that behavioral problems in this subset of patients may be less related to impulsivity in motor control. Our findings provide further evidence that dopamine agonist medication impacts specific cognitive control processes and that the direction of its effects depends on individual differences in performance off medication.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.