ArticleCell proliferation2012
Secreted factors from adipose tissue increase adipogenic differentiation of mesenchymal stem cells.
Article in Cell proliferation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Difference in M2 Macrophage Infiltration Between Cell-Assisted Fat Graft and Biomaterial-Encapsulated Stem Cell-Assisted Fat Graft: An Experimental Animal Study.Medicina (Kaunas, Lithuania) · 2026Article
- Identification and Validation of Hub Genes and Construction of miRNA-Gene and Transcription Factor-Gene Networks in Adipogenesis of Mesenchymal Stem Cells.Stem cells international · 2024Article
- Secretome as a Tool to Treat Neurological Conditions: Are We Ready?International journal of molecular sciences · 2023Review
- Screening for genes, miRNAs and transcription factors of adipogenic differentiation and dedifferentiation of mesenchymal stem cells.Journal of orthopaedic surgery and research · 2023Article
- Multimodal Label-Free Monitoring of Adipogenic Stem Cell Differentiation Using Endogenous Optical Biomarkers.Advanced functional materials · 2021Article
- The development of laminin-alginate microspheres encapsulated with Ginsenoside Rg1 and ADSCs for breast reconstruction after lumpectomy.Bioactive materials · 2021Article
- Adipocyte-progenitor cell communication that influences adipogenesis.Cellular and molecular life sciences : CMLS · 2020Review
- Secretome of Mesenchymal Stem Cells and Its Potential Protective Effects on Brain Pathologies.Molecular neurobiology · 2019Review
- The Role of Peroxisome Proliferator–Activated Receptor Gamma (PPARγ) in Mono(2-ethylhexyl) Phthalate (MEHP)-Mediated Cytotrophoblast Differentiation.Environmental health perspectives · 2019Article
- Evaluation of a laminin-alginate biomaterial, adipocytes, and adipocyte-derived stem cells interaction in animal autologous fat grafting model using 7-Tesla magnetic resonance imaging.Journal of materials science. Materials in medicine · 2017Article
- Therapeutic applications of conditioned medium from adipose tissue.Cell proliferation · 2016Review
- Decellularized human amniotic membrane: how viable is it as a delivery system for human adipose tissue-derived stromal cells?Cell proliferation · 2016Article
- Opportunities and challenges in three-dimensional brown adipogenesis of stem cells.Biotechnology advances · 2015Review
- Actions of endocrine-disrupting chemicals on stem/progenitor cells during development and disease.Endocrine-related cancer · 2014Review
- Dynamic protein pathway activation mapping of adipose-derived stem cell differentiation implicates novel regulators of adipocyte differentiation.Molecular & cellular proteomics : MCP · 2013Article
- The role of paracrine and autocrine signaling in the early phase of adipogenic differentiation of adipose-derived stem cells.PloS one · 2013Article
- Regenerative strategies for craniofacial disorders.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAdipose tissue engineering is one of the hottest topics in the field of regenerative medicine. Fat tissue has been considered as an abundant and accessible source of adult stem cells by tissue engineers, since it gives rise to adipose stem cells. However, recent reports have pointed out that adipose tissue, as a secretory and endocrine organ, might secrete cytokines that regulate body functions such as metabolism, infammation and more. In this study, we aim to investigate the adipogenic-inducing factors secreted by fat tissue. MATERIALS AND
methodsConditioned medium were collected by culturing fat tissue fragments in plastic flasks. Mesenchymal stem cells (MSCs) cultured in conditioned medium (CM) to test the adipogenic-inducing factors. Oil red O staining, reverse transcription/polymerase chain reaction and immunocytofluorescent staining were performed to examine the differentiation of MSCs in CM.
resultsMSCs cultured in CM of adipose tissue spontaneously differentiated into adipocytes. Furthermore, supplementation of insulin or dexamethasone to CM accelerated the process of lipid accumulation of differentiated MSCs. DISCUSSION: Results from this study demonstrated that fat tissues secrete small molecules, which induce adipogenic differentiation of MSCs.
conclusionsOur study provides clues for improving adipose tissue engineering by using fragmented adipose tissue as sources of fat-inducing factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.