Evidence map›Paper›PMID 22571349›Full record

ArticleBrain connectivity2012

Interhemispheric effective and functional cortical connectivity signatures of spina bifida are consistent with callosal anomaly.

Sheida Malekpour, Zhimin Li, Bing Leung Patrick Cheung, Eduardo M Castillo, Andrew C Papanicolaou, Larry A Kramer, Jack M Fletcher, Barry D Van Veen

Abstract read
In one paragraph

Article in Brain connectivity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sheida MalekpourDepartment of Electrical and Computer Engineering, University of Wisconsin, Madison, WI 53706, USA.
Zhimin Li
Bing Leung Patrick Cheung
Eduardo M Castillo
Andrew C Papanicolaou
Larry A Kramer
Jack M Fletcher
Barry D Van Veen

Funding

SUBJECT RECRUITMENT AND EVALUATION COREP01HD035946 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FLETCHER, JACK M · 1998 to 2009
$10.8M
EEG Estimation of Cortical ConnectivityR21EB009749 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI VAN VEEN, BARRY D · 2010 to 2011
$385k
NIBIB NIH HHS R21 EB009749NIBIB NIH HHS R21EB009749NICHD NIH HHS P01-HD35946
6 · The paper itself

Abstract

The impact of the posterior callosal anomalies associated with spina bifida on interhemispheric cortical connectivity is studied using a method for estimating cortical multivariable autoregressive models from scalp magnetoencephalography data. Interhemispheric effective and functional connectivity, measured using conditional Granger causality and coherence, respectively, is determined for the anterior and posterior cortical regions in a population of five spina bifida and five control subjects during a resting eyes-closed state. The estimated connectivity is shown to be consistent over the randomly selected subsets of the data for each subject. The posterior interhemispheric effective and functional connectivity and cortical power are significantly lower in the spina bifida group, a result that is consistent with posterior callosal anomalies. The anterior interhemispheric effective and functional connectivity are elevated in the spina bifida group, a result that may reflect compensatory mechanisms. In contrast, the intrahemispheric effective connectivity is comparable in the two groups. The differences between the spina bifida and control groups are most significant in the θ and α bands.

Indexed as

Brain DiseasesCase-Control StudiesCorpus CallosumFemaleFunctional LateralityHumansHydrocephalusInfantMagnetic Resonance ImagingMagnetoencephalographyMaleModels, NeurologicalNeural PathwaysSpinal Dysraphism

Identifiers

PMID22571349
PMCPMC3621297

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.