Evidence map›Paper›PMID 22570765›Full record

ArticleJournal of parasitology research2012

Reactive oxygen species and nitric oxide in cutaneous leishmaniasis.

Maria Fátima Horta, Bárbara Pinheiro Mendes, Eric Henrique Roma, Fátima Soares Motta Noronha, Juan Pereira Macêdo, Luciana Souza Oliveira, Myrian Morato Duarte, Leda Quercia Vieira

Open access · goldAbstract read
In one paragraph

Article in Journal of parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 128 citations in OpenAlex.

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  11. Anti-leishmaniasis Effect ofAdvanced biomedical research · 2023
    Article
  12. Article
  13. Immune Responses in Leishmaniasis: An Overview.Tropical medicine and infectious disease · 2022
    Review
  14. Review
  15. The Ecto-5'nucleotidase/CD73 MediatesBioMed research international · 2022
    Article
  16. Review
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Maria Fátima HortaDepartamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Bárbara Pinheiro Mendes
Eric Henrique Roma
Fátima Soares Motta Noronha
Juan Pereira Macêdo
Luciana Souza Oliveira
Myrian Morato Duarte
Leda Quercia Vieira
Universidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cutaneous leishmaniasis affects millions of people around the world. Several species of Leishmania infect mouse strains, and murine models closely reproduce the cutaneous lesions caused by the parasite in humans. Mouse models have enabled studies on the pathogenesis and effector mechanisms of host resistance to infection. Here, we review the role of nitric oxide (NO), reactive oxygen species (ROS), and peroxynitrite (ONOO(-)) in the control of parasites by macrophages, which are both the host cells and the effector cells. We also discuss the role of neutrophil-derived oxygen and nitrogen reactive species during infection with Leishmania. We emphasize the role of these cells in the outcome of leishmaniasis early after infection, before the adaptive T(h)-cell immune response.

Identifiers

PMID22570765
PMCPMC3337613
OpenAlexW1998188951

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.