ArticlePloS one2012
Viral findings in adult hematological patients with neutropenia.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Pathogen Detection by Metagenomic Next-Generation Sequencing During Neutropenic Fever in Patients With Hematological Malignancies.Open forum infectious diseases · 2022Article
- Rapid DNA visual detection of polymicrobial bloodstream infection using filter paper.Scientific reports · 2022Article
- Metagenomic shotgun sequencing of blood to identify bacteria and viruses in leukemic febrile neutropenia.PloS one · 2022Article
- Update in Viral Infections in the Intensive Care Unit.Frontiers in medicine · 2021Review
- Beyond Cytomegalovirus and Epstein-Barr Virus: a Review of Viruses Composing the Blood Virome of Solid Organ Transplant and Hematopoietic Stem Cell Transplant Recipients.Clinical microbiology reviews · 2020Review
- Co-infections of human herpesviruses (CMV, HHV-6, HHV-7 and EBV) in non-transplant acute leukemia patients undergoing chemotherapy.Virology journal · 2020Article
- Are Community Acquired Respiratory Viral Infections an Underestimated Burden in Hematology Patients?Microorganisms · 2019Review
- Community-acquired respiratory infections are common in patients with non-Hodgkin lymphoma and multiple myeloma.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018Article
- Update on Human Rhinovirus and Coronavirus Infections.Seminars in respiratory and critical care medicine · 2016Review
- Presence of rhinovirus in the respiratory tract of adolescents and young adults with asthma without symptoms of infection.Respiratory medicine · 2016Article
- Metagenomic analysis of bloodstream infections in patients with acute leukemia and therapy-induced neutropenia.Scientific reports · 2016Article
- Epidemiology of respiratory viruses in bronchoalveolar lavage samples in a tertiary hospital.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2014Article
- An Association between BK Virus Replication in Bone Marrow and Cytopenia in Kidney-Transplant Recipients.Journal of transplantation · 2014Article
- Human parvovirus B19 in pediatric and adult recipients of allogeneic hematopoietic stem cell transplantation.Bone marrow transplantation · 2013Article
- Clinical and economical impact of multiplex respiratory virus assays.Diagnostic microbiology and infectious disease · 2013Review
- Microbial translocation contribute to febrile episodes in adults with chemotherapy-induced neutropenia.PloS one · 2013Article
- Human rhinoviruses.Clinical microbiology reviews · 2013Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUntil recently, viral infections in patients with hematological malignancies were concerns primarily in allogeneic hematopoietic stem cell transplant (HSCT) recipients. During the last years, changed treatment regimens for non-transplanted patients with hematological malignancies have had potential to increase the incidence of viral infections in this group. In this study, we have prospectively investigated the prevalence of a broad range of respiratory viruses in nasopharyngeal aspirate (NPA) as well as viruses that commonly reactivate after allogeneic HSCT. METHODOLOGY/PRINCIPAL
findingsPatients with hematological malignancies and therapy induced neutropenia (n = 159) were screened regarding a broad range of common respiratory viruses in the nasopharynx and for viruses commonly detected in severely immunosuppressed patients in peripheral blood. Quantitative PCR was used for detection of viruses. A viral pathogen was detected in 35% of the patients. The detection rate was rather similar in blood (22%) and NPA (18%) with polyoma BK virus and rhinovirus as dominating pathogens in blood and NPA, respectively. Patients with chronic lymphocytic leukemia (CLL) (p<0.01) and patients with fever (p<0.001) were overrepresented in the virus-positive group. Furthermore, viral findings in NPA were associated with upper respiratory symptoms (URTS) (p<0.0001). CONCLUSIONS/SIGNIFICANCE: Both respiratory viral infections and low titers of viruses in blood from patients with neutropenia were common. Patients with CLL and patients with fever were independently associated to these infections, and viral findings in NPA were associated to URTS indicating active infection. These findings motivate further studies on viruses' impact on this patient category and their potential role as causative agents of fever during neutropenia.
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