ArticlePLoS genetics2012
LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Meta-analysis of expression of l(3)mbt tumor-associated germline genes supports the model that a soma-to-germline transition is a hallmark of human cancers.International journal of cancer · 2014Pooled it
- Unveiling the Tumor Suppressors: Insights from Drosophila.Advances in experimental medicine and biology · 2025Review
- Article
- Lint-O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brain.EMBO reports · 2022Article
- Article
- In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila.Nature communications · 2020Article
- Epigenetic Regulator CoREST Controls Social Behavior in Ants.Molecular cell · 2020Article
- Distinct CoREST complexes act in a cell-type-specific manner.Nucleic acids research · 2019Article
- The histone code reader PHD finger protein 7 controls sex-linked disparities in gene expression and malignancy inScience advances · 2019Article
- The same domain of Su(Hw) is required for enhancer blocking and direct promoter repression.Scientific reports · 2019Article
- L(3)mbt and the LINT complex safeguard cellular identity in theDevelopment (Cambridge, England) · 2018Article
- RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1.The EMBO journal · 2017Article
- AnOpen biology · 2017Article
- EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes.Nature communications · 2017Article
- Oncogenic transformation of Drosophila somatic cells induces a functional piRNA pathway.Genes & development · 2016Article
- Sex comb on midleg (Scm) is a functional link between PcG-repressive complexes in Drosophila.Genes & development · 2015Article
- CoREST1 promotes tumor formation and tumor stroma interactions in a mouse model of breast cancer.PloS one · 2015Article
- Chromatin regulation: how complex does it get?Epigenetics · 2014Review
- Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The insulator protein Suppressor of Hairy-wing is an essential transcriptional repressor in the Drosophila ovary.Development (Cambridge, England) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in the l(3)mbt tumour suppressor result in overproliferation of Drosophila larval brains. Recently, the derepression of different gene classes in l(3)mbt mutants was shown to be causal for transformation. However, the molecular mechanisms of dL(3)mbt-mediated gene repression are not understood. Here, we identify LINT, the major dL(3)mbt complex of Drosophila. LINT has three core subunits-dL(3)mbt, dCoREST, and dLint-1-and is expressed in cell lines, embryos, and larval brain. Using genome-wide ChIP-Seq analysis, we show that dLint-1 binds close to the TSS of tumour-relevant target genes. Depletion of the LINT core subunits results in derepression of these genes. By contrast, histone deacetylase, histone methylase, and histone demethylase activities are not required to maintain repression. Our results support a direct role of LINT in the repression of brain tumour-relevant target genes by restricting promoter access.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.