ArticlePLoS genetics2012
Patterns of ancestry, signatures of natural selection, and genetic association with stature in Western African pygmies.
Article in PLoS genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed, 141 citations in OpenAlex.
- Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
- Identification of Genomic Differences Resulting from Selection in Iranian Kurdish and Turkmen Horse Breeds Using Single Nucleotide Polymorphisms.Iranian journal of biotechnology · 2026Article
- Deep history of cultural and linguistic evolution among Central African hunter-gatherers.Nature human behaviour · 2024Article
- Genomic imputation of ancient Asian populations contrasts local adaptation in pre- and post-agricultural Japan.iScience · 2024Article
- SVhawkeye: an ultra-fast software for user-friendly visualization of targeted structural fragments from BAM files.Frontiers in genetics · 2024Article
- Evolutionary Genetics and Admixture in African Populations.Genome biology and evolution · 2023Review
- Article
- Comprehensive evaluation of structural variant genotyping methods based on long-read sequencing data.BMC genomics · 2022Article
- A Deep-Learning Approach for Inference of Selective Sweeps from the Ancestral Recombination Graph.Molecular biology and evolution · 2022Article
- High Genetic Diversity andFrontiers in cellular and infection microbiology · 2022Article
- Multi-omic profiling of pituitary thyrotropic cells and progenitors.BMC biology · 2021Article
- Human genetic admixture.PLoS genetics · 2021Review
- Identifying adaptive alleles in the human genome: from selection mapping to functional validation.Human genetics · 2021Review
- Unravelling selection signatures in a single dog breed suggests recent selection for morphological and behavioral traits.Advanced genetics (Hoboken, N.J.) · 2020Article
- Identification of novel genetic variants associated with short stature in a Baka Pygmies population.Human genetics · 2020Article
- Human adaptation over the past 40,000 years.Current opinion in genetics & development · 2020Review
- The importance of including ethnically diverse populations in studies of quantitative trait evolution.Current opinion in genetics & development · 2020Review
- Lifestyle and the presence of helminths is associated with gut microbiome composition in Cameroonians.Genome biology · 2020Article
- From Summary Statistics to Gene Trees: Methods for Inferring Positive Selection.Trends in genetics : TIG · 2020Review
- Adaptive introgression from indicine cattle into white cattle breeds from Central Italy.Scientific reports · 2020Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
African Pygmy groups show a distinctive pattern of phenotypic variation, including short stature, which is thought to reflect past adaptation to a tropical environment. Here, we analyze Illumina 1M SNP array data in three Western Pygmy populations from Cameroon and three neighboring Bantu-speaking agricultural populations with whom they have admixed. We infer genome-wide ancestry, scan for signals of positive selection, and perform targeted genetic association with measured height variation. We identify multiple regions throughout the genome that may have played a role in adaptive evolution, many of which contain loci with roles in growth hormone, insulin, and insulin-like growth factor signaling pathways, as well as immunity and neuroendocrine signaling involved in reproduction and metabolism. The most striking results are found on chromosome 3, which harbors a cluster of selection and association signals between approximately 45 and 60 Mb. This region also includes the positional candidate genes DOCK3, which is known to be associated with height variation in Europeans, and CISH, a negative regulator of cytokine signaling known to inhibit growth hormone-stimulated STAT5 signaling. Finally, pathway analysis for genes near the strongest signals of association with height indicates enrichment for loci involved in insulin and insulin-like growth factor signaling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.