ArticlePLoS computational biology2012
Deconvolution of the cellular force-generating subsystems that govern cytokinesis furrow ingression.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- The RNA-binding protein RNP1A is essential and interacts with contractility kit proteins to facilitate cell mechanics.Journal of cell science · 2026Article
- Discovery and Quantitative Dissection of Cytokinesis Mechanisms Using Dictyostelium discoideum.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Stability of asymmetric cell division: A deformable cell model of cytokinesis applied to C. elegans.Biophysical journal · 2023Article
- The Giardia ventrolateral flange is a lamellar membrane protrusion that supports attachment.PLoS pathogens · 2022Article
- A mesoscale mechanical model of cellular interactions.Biophysical journal · 2021Article
- Tools for computational analysis of moving boundary problems in cellular mechanobiology.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Nek8445, a protein kinase required for microtubule regulation and cytokinesis inMolecular biology of the cell · 2020Article
- The Unusual Suspects in Cytokinesis: Fitting the Pieces Together.Frontiers in cell and developmental biology · 2020Review
- How the mechanobiome drives cell behavior, viewed through the lens of control theory.Journal of cell science · 2019Review
- Meddling with myosin's mechanobiology in cancer.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Review
- Molecular Mechanism of Cytokinesis.Annual review of biochemistry · 2019Review
- Network Contractility During Cytokinesis-from Molecular to Global Views.Biomolecules · 2019Review
- Myosin IIB assembly state determines its mechanosensitive dynamics.The Journal of cell biology · 2019Article
- Contractility kits promote assembly of the mechanoresponsive cytoskeletal network.Journal of cell science · 2019Article
- Unite to divide - how models and biological experimentation have come together to reveal mechanisms of cytokinesis.Journal of cell science · 2018Review
- Micropipette Aspiration of Oocytes to Assess Cortical Tension.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Recent advances in cytokinesis: understanding the molecular underpinnings.F1000Research · 2018Review
- Cytokinesis in Metazoa and Fungi.Cold Spring Harbor perspectives in biology · 2017Review
- Myosin-independent cytokinesis inProceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Cytokinesis occurs through the coordinated action of several biochemically-mediated stresses acting on the cytoskeleton. Here, we develop a computational model of cellular mechanics, and using a large number of experimentally measured biophysical parameters, we simulate cell division under a number of different scenarios. We demonstrate that traction-mediated protrusive forces or contractile forces due to myosin II are sufficient to initiate furrow ingression. Furthermore, we show that passive forces due to the cell's cortical tension and surface curvature allow the furrow to complete ingression. We compare quantitatively the furrow thinning trajectories obtained from simulation with those observed experimentally in both wild-type and myosin II null Dictyostelium cells. Our simulations highlight the relative contributions of different biomechanical subsystems to cell shape progression during cell division.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.