ArticlePhysiological genomics2012
Genomics of estradiol-3-sulfate action in the ovine fetal hypothalamus.
Article in Physiological genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Maternal hypercortisolemia alters placental metabolism: a multiomics view.American journal of physiology. Endocrinology and metabolism · 2020Article
- Fetal ovine skeletal and cardiac muscle transcriptomics are differentially altered by increased maternal cortisol during gestation.Physiological genomics · 2020Article
- Differential gene responses 3 days following infarction in the fetal and adolescent sheep heart.Physiological genomics · 2020Article
- Mechanisms of in utero cortisol effects on the newborn heart revealed by transcriptomic modeling.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Oxidant stress induction and signalling in xenografted (human breast cancer-tissues) plus estradiol treated or N-ethyl-N-nitrosourea treated female rats via altered estrogen sulfotransferase (rSULT1E1) expressions and SOD1/catalase regulations.Molecular biology reports · 2018Article
- Multiomics approach reveals metabolic changes in the heart at birth.American journal of physiology. Endocrinology and metabolism · 2018Article
- Effects of ketamine on the fetal transcriptomic response to umbilical cord occlusion: comparison with hypoxic hypoxia in the cerebral cortex.The Journal of physiology · 2018Article
- Mapping Molecular Datasets Back to the Brain Regions They are Extracted from: Remembering the Native Countries of Hypothalamic Expatriates and Refugees.Advances in neurobiology · 2018Article
- Genomic Effect of Triclosan on the Fetal Hypothalamus: Evidence for Altered Neuropeptide Regulation.Endocrinology · 2016Article
- Ketamine decreases inflammatory and immune pathways after transient hypoxia in late gestation fetal cerebral cortex.Physiological reports · 2016Article
- Ketamine suppresses hypoxia-induced inflammatory responses in the late-gestation ovine fetal kidney cortex.The Journal of physiology · 2016Article
- Transcriptomics Modeling of the Late-Gestation Fetal Pituitary Response to Transient Hypoxia.PloS one · 2016Article
- Patterns of gene expression in the sheep heart during the perinatal period revealed by transcriptomic modeling.Physiological genomics · 2015Article
- Mechanisms for the adverse effects of late gestational increases in maternal cortisol on the heart revealed by transcriptomic analyses of the fetal septum.Physiological genomics · 2014Article
- Mineralocorticoid effects in the late gestation ovine fetal lung.Physiological reports · 2014Article
- Transcriptomics of the fetal hypothalamic response to brachiocephalic occlusion and estradiol treatment.Physiological genomics · 2014Article
- Genomics of the fetal hypothalamic cellular response to transient hypoxia: endocrine, immune, and metabolic responses.Physiological genomics · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
In fetal sheep during late gestation sulfoconjugated estrogens in plasma reach a concentration 40-100 times greater than unconjugated estrogens. The objective of the present study was to determine the genomics of estradiol-3-sulfate (E(2)S) action in the ovine fetal brain. The hypothesis was that E(2)S stimulates genes involved in the neuroendocrine pathways that direct or facilitate fetal development at the end of gestation. Four sets of chronically catheterized ovine twin fetuses were studied (gestational age: 120-127 days gestation) with one infused with E(2)S intracerebroventricularly (1 mg/day) and the other remaining untreated (control). After euthanasia, mRNA samples were extracted from fetal brains. Only hypothalamic samples were employed for this study given the important function of this brain region in the control of the hypothalamus-pituitary-adrenal axis. Microarray analysis was performed following the Agilent protocol for one-color 8 × 15 microarrays, designed for Ovis aries. A total of 363 known genes were significantly upregulated by the E(2)S treatment (P < 0.05). Network and enrichment analyses were performed using the Cytoscape/Bingo software, and the results validated by quantitative real-time PCR. The main overrepresented biological processes resulting from this analysis were feeding behavior, hypoxia response, and transforming growth factor signaling. Notably, the genes involved in the feeding behavior (neuropeptide Y and agouti-related protein) were the most strongly induced by the E(2)S treatment. In conclusion, E(2)S may be an important component of the mechanism for activating orexigenic, hypoxia responsiveness and neuroprotective pathways in the lamb as it approaches postnatal life.
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Registered trials
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