ArticleInvestigative ophthalmology & visual science2012
A few good responses: which mechanical effects of IOP on the ONH to study?
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Lamina Cribrosa Hypoxia Sensitivity to Variations of Anatomy and Vascular Factors.Journal of biomechanical engineering · 2025Article
- Topical Application of a Collagen Mimetic Peptide Restores Peripapillary Scleral Stiffness Reduced by Ocular Stress.Pharmaceuticals (Basel, Switzerland) · 2025Article
- The association between asymmetric stress distribution on the lamina cribrosa and glaucoma progression.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Impact of anatomic variability and other vascular factors on lamina cribrosa hypoxia.bioRxiv : the preprint server for biology · 2024Article
- Impact of elevated IOP on lamina cribrosa oxygenation; A combined experimental-computational study on monkeys.bioRxiv : the preprint server for biology · 2024Article
- The Robust Lamina Cribrosa Vasculature: Perfusion and Oxygenation Under Elevated Intraocular Pressure.Investigative ophthalmology & visual science · 2024Article
- Lamina Cribrosa Insertions Into the Sclera Are Sparser, Narrower, and More Slanted in the Anterior Lamina.Investigative ophthalmology & visual science · 2024Article
- Direct measurements of collagen fiber recruitment in the posterior pole of the eye.Acta biomaterialia · 2024Article
- The Curvature, Collagen Network Structure, and Their Relationship to the Pressure-Induced Strain Response of the Human Lamina Cribrosa in Normal and Glaucoma Eyes.Journal of biomechanical engineering · 2023Article
- Who bears the load? IOP-induced collagen fiber recruitment over the corneoscleral shell.Experimental eye research · 2023Article
- High-Frequency Ultrasound Elastography to Assess the Nonlinear Elastic Properties of the Cornea and Ciliary Body.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2022Article
- Eye-specific 3D modeling of factors influencing oxygen concentration in the lamina cribrosa.Experimental eye research · 2022Article
- Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo.Experimental eye research · 2021Article
- Strain by virtual extensometers and video-imaging optical coherence tomography as a repeatable metric for IOP-Induced optic nerve head deformations.Experimental eye research · 2021Article
- Role of radially aligned scleral collagen fibers in optic nerve head biomechanics.Experimental eye research · 2020Article
- Factors affecting optic nerve head biomechanics in a rat model of glaucoma.Journal of the Royal Society, Interface · 2020Article
- Cerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics.Investigative ophthalmology & visual science · 2018Article
- The connective tissue phenotype of glaucomatous cupping in the monkey eye - Clinical and research implications.Progress in retinal and eye research · 2017Review
- What is a typical optic nerve head?Experimental eye research · 2016Article
- Age- and race-related differences in human scleral material properties.Investigative ophthalmology & visual science · 2014Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
purposeThe biomechanical effects of IOP on the optic nerve head (ONH) are believed to play a role in glaucomatous neuropathy. There is, however, no consensus on which effects of IOP should be prioritized for investigation. Our goal was to identify a small set of variables capturing the majority of the effects of acute IOP on the ONH.
methodsWe produced 4646 finite element models of the human ONH representing a wide range of tissue anatomies and mechanical properties. The effects of IOP were quantified through a set of 25 responses including stress, strain, and geometric deformation of the lamina cribrosa (LC) and peripapillary sclera. The correlations between the responses were analyzed and principal component analysis (PCA) was used to identify uncorrelated variables capturing the largest possible variance in the responses.
resultsThe responses formed groups with strong correlations. The top five principal components (PCs) accounted for 72.8%, 13.0%, 7.1%, 3.1%, and 2.0% of the variance, respectively.
conclusionsFew PCs capture the majority of the mechanical effects of acute changes in IOP on the ONH, which previously required 25 measures. The PCs represented four key effects of IOP: lateral deformation associated with canal expansion (PC1), anterior-posterior deformation of the LC and the forces through it determined by either the mechanical properties of the LC (PC2) or of the neural tissue (PC4), rotation of the peripapillary sclera (PC5), and forces through the peripapillary sclera (PC3). A small set of uncorrelated variables will simplify describing and understanding the effects of IOP on the ONH.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.