ArticleInvestigative ophthalmology & visual science2012
Cone photoreceptor packing density and the outer nuclear layer thickness in healthy subjects.
Article in Investigative ophthalmology & visual science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
41 citing papers in PubMed, 65 citations in OpenAlex.
- REPEATABILITY AND LONGITUDINAL ASSESSMENT OF FOVEAL CONE STRUCTURE IN CNGB3-ASSOCIATED ACHROMATOPSIA.Retina (Philadelphia, Pa.) · 2017Trial
- Correlation of outer nuclear layer thickness with cone density values in patients with retinitis pigmentosa and healthy subjects.Investigative ophthalmology & visual science · 2014Trial
- Henle Fibers Are Organized in Bundles Consistent Between Individuals and Conserved in Primates.Investigative ophthalmology & visual science · 2026Article
- Developing Clinically Implementable Approaches for Directional Optical Coherence Tomography.Translational vision science & technology · 2026Article
- Selected Aspects of Optical Coherence Tomography and Adaptive Optics in Patients with Increased Body Mass Index.Biomedicines · 2026Article
- Assessing the Relationship between Foveal Cone Density, Outer Nuclear Layer Thickness and Foveal Morphology.Ophthalmology science · 2026Article
- Three-dimensional tissue engineering and organoid technologies for retinal regeneration and therapy.Bioengineering & translational medicine · 2025Review
- Longitudinal Imaging of the Foveal Cone Mosaic in CNGA3-Associated Achromatopsia.Investigative ophthalmology & visual science · 2024Article
- Modeling rod and cone photoreceptor cell survival in vivo using optical coherence tomography.Scientific reports · 2023Article
- Volumetric directional optical coherence tomography.Biomedical optics express · 2022Article
- Foveal Phase Retardation Correlates With Optically Measured Henle Fiber Layer Thickness.Frontiers in medicine · 2022Article
- Variability in Retinal Neuron Populations and Associated Variations in Mass Transport Systems of the Retina in Health and Aging.Frontiers in aging neuroscience · 2022Review
- Cone Photoreceptors in Diabetic Patients.Frontiers in medicine · 2022Article
- The effect of retinal scaffold modulus on performance during surgical handling.Experimental eye research · 2021Article
- Current Insights Into 3D Bioprinting: An Advanced Approach for Eye Tissue Regeneration.Pharmaceutics · 2021Review
- The Relationship Between Perifoveal L-Cone Isolating Visual Acuity and Cone Photoreceptor Spacing-Understanding the Transition Between Healthy Aging and Early AMD.Frontiers in aging neuroscience · 2021Article
- Cones in ageing and harsh environments: the neural economy hypothesis.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2020Review
- Spatial-sweep steady-state pattern electroretinography can detect subtle differences in visual function among healthy adults.Scientific reports · 2019Article
- Assessing the Interocular Symmetry of Foveal Outer Nuclear Layer Thickness in Achromatopsia.Translational vision science & technology · 2019Article
- Two-photon polymerized poly(caprolactone) retinal cell delivery scaffolds and their systemic and retinal biocompatibility.Acta biomaterialia · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeWe evaluated the relationship between cone photoreceptor packing density and outer nuclear layer (ONL) thickness within the central 15 degrees.
methodsIndividual differences for healthy subjects in cone packing density and ONL thickness were examined in 8 younger and 8 older subjects, mean age 27.2 versus 56.2 years. Cone packing density was obtained using an adaptive optics scanning laser ophthalmoscope (AOSLO). The ONL thickness measurements included the ONL and the Henle fiber layer (ONL + HFL), and were obtained using spectral domain optical coherence tomography (SDOCT) and custom segmentation software.
resultsThere were sizeable individual differences in cone packing density and ONL + HFL thickness. Older subjects had on average lower cone packing densities, but thicker ONL + HFL measurements. Cone packing density and ONL + HFL thickness decreased with increasing retinal eccentricity. The ratio of the cone packing density-to-ONL2 was larger for the younger subjects group, and decreased with retinal eccentricity.
conclusionsThe individual differences in cone packing density and ONL + HFL thickness are consistent with aging changes, indicating that normative aging data are necessary for fine comparisons in the early stages of disease or response to treatment. Our finding of ONL + HFL thickness increasing with aging is inconsistent with the hypothesis that ONL measurements with SDOCT depend only on the number of functioning cones, since in our older group cones were fewer, but thickness was greater.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.