Evidence map›Paper›PMID 22570317›Full record

SynthesisJournal of the National Cancer Institute2012

Physical activity, biomarkers, and disease outcomes in cancer survivors: a systematic review.

Rachel Ballard-Barbash, Christine M Friedenreich, Kerry S Courneya, Sameer M Siddiqi, Anne McTiernan, Catherine M Alfano

6 registry-linked trialsOpen access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of the National Cancer Institute, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 420 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
420citing papers in PubMed, 13 pooled it
35.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01982994 nacompletednot on this mapstarted 2013, after this paper: background citation

Intervention to Motivate Standing &Walking in Gastrointestinal Cancer Surgical Patients

TypeinterventionalSponsorMilton S. Hershey Medical CenterRan2013 to 2018Enrolled32ConditionsGastrointestinal NeoplasmsArmsEducation/Daily Planning
NCT04616300 recruitingnot on this mapstarted 2019, after this paper: background citation

Cardiorespiratory Fitness, Inflammatory Biomarkers, and Cognitive Function Patterns During Treatment for Breast Cancer: a Prospective Cohort Study

Typeobservational_patient_registrySponsorUniversity of TorontoRan2019 to 2025Enrolled50ConditionsBreast Cancer
NCT05009849 naactive not recruitingnot on this map

Randomized Controlled Evaluating the Role of Exercise in Women Undergoing Treatment for Breast Cancer

TypeinterventionalSponsorTata Memorial CentreRan2010 to 2030Enrolled850ConditionsBreast Cancer PatientsArmsYoga Exercises
NCT05375162 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Optimization of a mHealth Physical Activity Promotion Intervention With Mindful Awareness for Adolescent and Young Adult Cancer Survivors

TypeinterventionalSponsorNorthwestern UniversityRan2023 to 2026Enrolled304ConditionsCancerArmsCore Intervention, E-Coach, General Mindfulness Training, MVPA-Specific Mindfulness Training, Buddy
NCT05401045 nacompletednot on this mapstarted 2023, after this paper: background citation

Effect of a Self-designed Metabolic Equivalent Exercise Intervention on Cancer-related Fatigue in Patients With Gastric Cancer

TypeinterventionalSponsorRuijin HospitalRan2023 to 2023Enrolled119ConditionsNeoplasm of StomachArmsMet exercises
NCT05931874 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation

Fit2ThriveMIND: Optimizing a mHealth Physical Activity Intervention With Mindful Awareness Lessons in Breast Cancer Survivors

TypeinterventionalSponsorNorthwestern UniversityRan2024 to 2027Enrolled304ConditionsBreast CancerArmsCore Intervention, E-Coach, Buddy, General Mindfulness Training, MVPA-Specific Mindfulness Training
3 · Its place in the literature

Who cites it

420 citing papers in PubMed, 13 syntheses or guidelines pooled it, 842 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. The Effects of Post-diagnosis Recreational Aerobic Exercise among Breast Cancer Survivors: A Systematic Review/Meta-Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Pooled it
  5. Pooled it
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  7. Benefits of weight loss programs for breast cancer survivors: a systematic reviews and meta-analysis of randomized controlled trials.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2022
    Pooled it
  8. Pooled it
  9. Pooled it
  10. The requirements of a specialist breast centre.Breast (Edinburgh, Scotland) · 2020
    Guideline
  11. Effects of exercise interventions on social and cognitive functioning of men with prostate cancer: a meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020
    Pooled it
  12. Physical activity programs for children diagnosed with cancer: an international environmental scan.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2019
    Pooled it
  13. Pooled it
  14. Trial
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  16. Effects of a Physical Activity mHealth Intervention (Fit2Thrive) on WCRF/AICR Cancer Prevention Recommendations among Breast Cancer Survivors: A Secondary Data Analysis.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Trial
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360 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Rachel Ballard-BarbashApplied Research Program, Department of Health and Human Services, Division of Cancer Control and Population Sciences, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892-7344, USA. barbashr@mail.nih.gov
Christine M Friedenreich
Kerry S Courneya
Sameer M Siddiqi
Anne McTiernan
Catherine M Alfano
Alberta Health Services · CANational Coalition for Cancer Survivorship · USNational Institutes of Health · USUniversity of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCancer survivors often seek information about how lifestyle factors, such as physical activity, may influence their prognosis. We systematically reviewed studies that examined relationships between physical activity and mortality (cancer-specific and all-cause) and/or cancer biomarkers.

methodsWe identified 45 articles published from January 1950 to August 2011 through MEDLINE database searches that were related to physical activity, cancer survival, and biomarkers potentially relevant to cancer survival. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Statement to guide this review. Study characteristics, mortality outcomes, and biomarker-relevant and subgroup results were abstracted for each article that met the inclusion criteria (ie, research articles that included participants with a cancer diagnosis, mortality outcomes, and an assessment of physical activity).

resultsThere was consistent evidence from 27 observational studies that physical activity is associated with reduced all-cause, breast cancer-specific, and colon cancer-specific mortality. There is currently insufficient evidence regarding the association between physical activity and mortality for survivors of other cancers. Randomized controlled trials of exercise that included biomarker endpoints suggest that exercise may result in beneficial changes in the circulating level of insulin, insulin-related pathways, inflammation, and, possibly, immunity; however, the evidence is still preliminary.

conclusionsFuture research directions identified include the need for more observational studies on additional types of cancer with larger sample sizes; the need to examine whether the association between physical activity and mortality varies by tumor, clinical, or risk factor characteristics; and the need for research on the biological mechanisms involved in the association between physical activity and survival after a cancer diagnosis. Future randomized controlled trials of exercise with biomarker and cancer-specific disease endpoints, such as recurrence, new primary cancers, and cancer-specific mortality in cancer survivors, are warranted.

Indexed as

Motor ActivityPhysical ExertionSurvivorsBiomarkers, TumorBreast NeoplasmsConfounding Factors, EpidemiologicExerciseHumansInflammationInsulinNeoplasmsPredictive Value of TestsPrognosisRandomized Controlled Trials as TopicTreatment OutcomeBiomarkers, TumorInsulin

Identifiers

PMID22570317
PMCPMC3465697
OpenAlexW2098094536

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.