ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2013
Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 67 citations in OpenAlex.
- Six-month Calorie Restriction in Overweight Individuals Elicits Transcriptomic Response in Subcutaneous Adipose Tissue That is Distinct From Effects of Energy Deficit.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Trial
- Bench to bedside: is rapamycin headed for the docTOR?GeroScience · 2026Review
- Less is more: calorie restriction as a therapeutic for mental health disorders.Frontiers in psychiatry · 2025Review
- Non-canonical metabolic and molecular effects of calorie restriction are revealed by varying temporal conditions.Cell reports · 2024Article
- Does diet influence aging? Evidence from animal studies.Journal of internal medicine · 2024Review
- Natural Modulators of Key Signaling Pathways in Skin Inflammageing.Clinical, cosmetic and investigational dermatology · 2024Review
- Combinatorial interventions in aging.Nature aging · 2023Review
- When a calorie is not just a calorie: Diet quality and timing as mediators of metabolism and healthy aging.Cell metabolism · 2023Review
- Review
- The mTOR signaling pathway in cardiac aging.The journal of cardiovascular aging · 2023Article
- Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle.Nature communications · 2022Article
- Article
- Molecular mechanisms of dietary restriction promoting health and longevity.Nature reviews. Molecular cell biology · 2022Review
- Antiaging diets: Separating fact from fiction.Science (New York, N.Y.) · 2021Review
- The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Targeting cellular senescence based on interorganelle communication, multilevel proteostasis, and metabolic control.The FEBS journal · 2021Review
- Molecular Regulation of Skeletal Muscle Growth and Organelle Biosynthesis: Practical Recommendations for Exercise Training.International journal of molecular sciences · 2021Review
- TOR Signaling Pathway in Cardiac Aging and Heart Failure.Biomolecules · 2021Review
- Still Living Better through Chemistry: An Update on Caloric Restriction and Caloric Restriction Mimetics as Tools to Promote Health and Lifespan.International journal of molecular sciences · 2020Review
- Rapamycin-mediated mouse lifespan extension: Late-life dosage regimes with sex-specific effects.Aging cell · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Because rapamycin, an inhibitor of the nutrient sensor mammalian target of rapamycin, and dietary restriction both increase life span of mice, it has been hypothesized that they act through similar mechanisms. To test this hypothesis, we compared various biological parameters in dietary restriction mice (40% food restriction) and mice fed rapamycin (14 ppm). Both treatments led to a significant reduction in mammalian target of rapamycin signaling and a corresponding increase in autophagy. However, we observed striking differences in fat mass, insulin sensitivity, and expression of cell cycle and sirtuin genes in mice fed rapamycin compared with dietary restriction. Thus, although both treatments lead to significant downregulation of mammalian target of rapamycin signaling, these two manipulations have quite different effects on other physiological functions suggesting that they might increase life span through a common pathway as well as pathways that are altered differently by dietary restriction and rapamycin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.