ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2013
Genetic regulation of life span, metabolism, and body weight in Pohn, a new wild-derived mouse strain.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Analysis of lifespan across diversity outbred mouse studies identifies multiple longevity-associated loci.Genetics · 2025Article
- Genealogical analysis of European bison population revealed a growing up population despite very low genetic diversity.PloS one · 2022Article
- Heritability of the aged glutathione phenotype is dependent on tissue of origin.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- Genetic cartography of longevity in humans and mice: Current landscape and horizons.Biochimica et biophysica acta. Molecular basis of disease · 2018Review
- Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region of chromosome 2.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Article
- The development and biological characteristics of a novel potentially radioresistant inbred mouse strain.Molecular medicine reports · 2017Article
- Heritability of in vitro phenotypes exhibited by murine adipose-derived stromal cells.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
- Lifespan modulation in mice and the confounding effects of genetic background.Journal of genetics and genomics = Yi chuan xue bao · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Quantitative trait loci (QTL) of longevity identified in human and mouse are significantly colocalized, suggesting that common mechanisms are involved. However, the limited number of strains that have been used in mouse longevity studies undermines the ability to identify longevity genes. We crossed C57BL/6J mice with a new wild-derived strain, Pohn, and identified two life span QTL-Ls1 and Ls2. Interestingly, homologous human longevity QTL colocalize with Ls1. We also defined new QTL for metabolic heat production and body weight. Both phenotypes are significantly correlated with life span. We found that large clone ratio, an in vitro indicator for cellular senescence, is not correlated with life span, suggesting that cell senescence and intrinsic aging are not always associated. Overall, by using Pohn mice, we identified new QTL for longevity-related traits, thus facilitating the exploration of the genetic regulation of aging.
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Registered trials
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