ArticleDevelopment genes and evolution2012
Activation of Hox genes during caudal regeneration of the polychaete annelid Platynereis dumerilii.
Article in Development genes and evolution, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 74 citations in OpenAlex.
- Transcriptomic analysis of three annelid species: looking for markers of positional information.BMC genomics · 2026Article
- Sex-specific differential gene expression during stolonization in the branching syllid Ramisyllis kingghidorahi (Annelida, Syllidae).BMC genomics · 2025Article
- Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model.Nature communications · 2024Article
- Transcriptomic landscape of posterior regeneration in the annelid Platynereis dumerilii.BMC genomics · 2023Article
- Article
- Cell Proliferation Indices in RegeneratingCells · 2023Article
- Morphological and molecular features of early regeneration in the marine annelid Ophryotrocha xiamen.Scientific reports · 2022Article
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Neural regulation of body polarities in nereid worm regeneration.FASEB bioAdvances · 2022Article
- DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.Development (Cambridge, England) · 2021Article
- Regeneration in the Segmented AnnelidGenes · 2021Review
- The Nereid on the rise: Platynereis as a model system.EvoDevo · 2021Review
- Maternal Transcripts of Hox Genes Are Found in Oocytes ofJournal of developmental biology · 2021Article
- Comparative Aspects of Annelid Regeneration: Towards Understanding the Mechanisms of Regeneration.Genes · 2021Review
- Injury-Induced Innate Immune Response During Segment Regeneration of the Earthworm,International journal of molecular sciences · 2021Article
- Article
- A Revised Spiralian Homeobox Gene Classification Incorporating New Polychaete Transcriptomes Reveals a Diverse TALE Class and a Divergent Hox Gene.Genome biology and evolution · 2018Article
- PdumBase: a transcriptome database and research tool for Platynereis dumerilii and early development of other metazoans.BMC genomics · 2018Article
- Regeneration mechanisms in Syllidae (Annelida).Regeneration (Oxford, England) · 2018Review
- ALKALs are in vivo ligands for ALK family receptor tyrosine kinases in the neural crest and derived cells.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The capability of regenerating posterior segments and pygidial structures is ancestral for annelids and has been lost only a few times within this phylum. As one of the three major segmented taxa, annelids enable us to monitor reconstruction of lost tissues and organs. During regeneration, regional identities have to be imprinted onto the newly formed segments. In this study, we show spatial and temporal localization of expression of nine Hox genes during caudal regeneration of the polychaete annelid Platynereis dumerilii. Hox genes are homeodomain genes encoding transcriptional regulators of axial patterning in bilaterian animals during development. We demonstrate that five Platynereis Hox genes belonging to paralog groups (PG) 1, 4, 5, 6, and 9-14 are expressed in domains of the regenerating nervous system consistent with providing positional information along the anteroposterior axis of the regenerate. We report that expression in regenerating neuromeres is limited to varying subsets of perikarya, called gangliosomes. Four of nine genes analyzed do not appear to be involved in axial patterning. Two genes, Pdu-Hox2 and Pdu-Hox3, are predominantly expressed in the growth zone region. For some Hox genes expression in newly formed coelomic epithelia can be observed. Platynereis Hox genes do not exhibit temporal or spatial colinearity. Although there are some similarities to previously reported expression patterns during larval and postlarval development in Nereididae (Kulakova et al. 2007), expression patterns observed during caudal regeneration also show unique patterns.
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