ArticleEndocrine pathology2012
Correlation between histological subtypes and MRI findings in clinically nonfunctioning pituitary adenomas.
Article in Endocrine pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Ki67 in endocrine neoplasms: to count or not to count, this is the question! A systematic review from the English language literature.Journal of endocrinological investigation · 2020Pooled it
- Clinical characteristics and prognostic outcomes of silent corticotroph versus gonadotroph adenomas: A 603-case single-center cohort study.Neurosurgical review · 2026Article
- Radiological and Immunohistochemical Characteristics of PitNETs in 79 Patients Undergoing Neurosurgery.Cancers · 2025Article
- Association between transcription factors expression and growth patterns of nonfunctioning pituitary adenomas.Scientific reports · 2025Article
- An update on, and genetics of refractory adenomas of childhood.Pituitary · 2023Review
- Distribution of E- and N-cadherin in subgroups of non-functioning pituitary neuroendocrine tumours.Endocrine · 2022Article
- Baseline MRI findings as predictors of hypopituitarism in patients with non-functioning pituitary adenomas.Endocrine connections · 2021Article
- Non-functioning pituitary adenomas and pregnancy: one-center experience and review of the literature.Archives of endocrinology and metabolism · 2021Review
- Aggressive pituitary tumors in the young and elderly.Reviews in endocrine & metabolic disorders · 2020Review
- MSH6/2 and PD-L1 Expressions Are Associated with Tumor Growth and Invasiveness in Silent Pituitary Adenoma Subtypes.International journal of molecular sciences · 2020Article
- Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas.Pituitary · 2018Review
- The Complementary Role of Transcription Factors in the Accurate Diagnosis of Clinically Nonfunctioning Pituitary Adenomas.Endocrine pathology · 2015Article
- Imaging of Resected Nonfunctioning Pituitary Adenomas: The Cost of Surveillance.Journal of neurological surgery. Part B, Skull base · 2015Article
- Pituitary macroadenoma: less common neuroimaging features in a common lesion.Radiologia brasileiraArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinically nonfunctioning pituitary adenomas (CNFPAs) consist of several histological subtypes, including null cell adenoma (NCA), silent gonadotroph cell adenoma (SGA), silent corticotroph adenoma (SCA), and other silent adenomas (OSA) (i.e., GH, TSH, and prolactin adenomas). To detect possible correlations between MRI findings and the subtypes, we retrospectively studied 390 consecutive patients with CNFPA who underwent surgery between 2008 and 2010. They were classified into three groups: NCA/SGA (313 cases), SCA (39 cases), and OSA (36 cases); in addition there were two unusual cases of plurihormonal adenoma. Three MRI findings were less common in NCA/SGA than in the other groups (P < 0.0001): giant adenoma (>40 mm), marked cavernous sinus invasion (Knosp grade 4), and lobulated configuration of the suprasellar tumor. When these MRI findings were negative in patients older than 40 years old, 91.0% (212/233) were NCA/SGA. These MRI findings were frequently noted despite a low MIB-1 index in SCA. OSA showed a high MIB-1 index and a preponderance in younger patients. In conclusion, although SCA and OSA consisted of only 20% of CNFPAs, their frequency significantly increased when the tumor was large, invasive, and lobulated, and the patient was younger than 40 years old.
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