SynthesisInternational urogynecology journal2012
Intravesical treatment of painful bladder syndrome: a systematic review and meta-analysis.
Synthesis in International urogynecology journal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Efficacy and safety comparison of pharmacotherapies for interstitial cystitis and bladder pain syndrome: a systematic review and Bayesian network meta-analysis.International urogynecology journal · 2021Pooled it
- A systematic review and meta-analysis on the efficacy of intravesical therapy for bladder pain syndrome/interstitial cystitis.International urogynecology journal · 2016Pooled it
- Treatment of bladder pain syndrome and interstitial cystitis: a systematic review.International urogynecology journal · 2016Pooled it
- Validation of Distinct Bladder Pain Phenotypes Utilizing the MAPP Research Network Cohort.International urogynecology journal · 2024Article
- Factors associated with treatment outcomes after intravesical hyaluronic acid therapy in women with refractory interstitial cystitis: A prospective, multicenter study.Journal of the Chinese Medical Association : JCMA · 2021Article
- Comparison of Intravesical Hyaluronic Acid, Chondroitin Sulfate, and Combination of Hyaluronic Acid-Chondroitin Sulfate Therapies in Animal Model of Interstitial Cystitis.International neurourology journal · 2021Article
- Intravesical treatment for interstitial cystitis/painful bladder syndrome: a network meta-analysis.International urogynecology journal · 2017Review
- Research on Novel Intravesical Drug Delivery Devices.International neurourology journal · 2016Article
- Grading of evidence for bladder pain syndrome: a comparative review of study quality assessment methods.International urogynecology journal · 2014Review
- TRP channels in lower urinary tract dysfunction.British journal of pharmacology · 2014Review
- Cyclophosphamide-induced cystitis reduces ASIC channel but enhances TRPV1 receptor function in rat bladder sensory neurons.Journal of neurophysiology · 2013Article
- Intravesical treatments of bladder pain syndrome/interstitial cystitis.Nature reviews. Urology · 2012Review
- Intravesical treatment of painful bladder syndrome: the potential pitfalls of meta-analyses.International urogynecology journal · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introduction and hypothesisThe objective of the study was to assess the effectiveness of intravesical treatment for painful bladder syndrome (PBS).
methodsA systematic review was performed until December 31, 2010. The selection criteria included only randomized controlled trials of PBS patients who received intravesical treatment. The primary outcomes measures were clinical and urodynamic parameters. Relative risk and mean differences were used for binary and continuous outcomes respectively, with confidence interval of 95%.
resultsThe search strategy identified 770; however, only 28 eligible trials met methodological requirements for complete analysis. Altogether, the review included four treatment modalities: resiniferatoxin, Bacillus Calmette-Guérin (BCG), oxybutynin, and alkalinized lidocaine. Meta-analysis of BCG therapy showed improvement in symptoms according to the Wisconsin Interstitial Cystitis Symptom Inventory, but no difference in 24-h urinary frequency.
conclusionsMeta-analysis showed an improvement exclusively of the symptoms as measured by the Wisconsin Interstitial Cystitis Inventory, but not in 24-h urinary frequency, with BCG therapy. Further randomized clinical trials, including trials of more recent drugs, are required for evaluation of intravesical therapies for PBS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.