ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2012
Acute stress induces selective alterations in cost/benefit decision-making.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 1 of them a synthesis that pooled it.
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Who cites it
90 citing papers in PubMed, 1 synthesis or guideline pooled it, 161 citations in OpenAlex.
- Dopaminergic modulation of reward discounting in healthy rats: a systematic review and meta-analysis.Psychopharmacology · 2021Pooled it
- Cellular and molecular coding of habit-driven behavior in the dorsal raphe nucleus.bioRxiv : the preprint server for biology · 2026Article
- Dissecting the contribution of mu and kappa opioid receptor signalling in effort and delay-related cost/benefit decision making.Psychopharmacology · 2026Article
- Alcohol or Stress Exposure During Late Adolescence Impairs Risk Assessment Later in Life, Disrupting the Ethological Structure of Behavior in Mice.Alcohol, clinical & experimental research · 2026Article
- Neurochemical drivers of effort: The roles of dopamine and beyond in physical and cognitive exertion.Neuroscience and biobehavioral reviews · 2026Review
- Behavioral Domain-Specific Effects of Positive Modulation of α5 and α6 GABAPharmacology research & perspectives · 2026Article
- Ketamine Improves Anhedonic Phenotypes Across Species: Translational Evidence From the Probabilistic Reward Task.Biological psychiatry global open science · 2026Article
- Impulsivity in NrCAM KO Mice Is Reduced by NMDAR Antagonist MK-801 but Not by AMPAR Antagonist CNQX.NeuroSci · 2026Article
- Impact of brief maternal separation on rodent models of anergia induced by dopamine depletion: analysis in mice of both sexes during adulthood.Psychopharmacology · 2025Article
- Home-Cage Training for Non-Human Primates: An Opportunity to Reduce Stress and Study Natural Behavior in Neurophysiology Experiments.Animals : an open access journal from MDPI · 2025Review
- Cross-species translational paradigms for assessing positive valence system as defined by the RDoC matrix.Journal of neurochemistry · 2025Review
- Willingness to wait covaries with endogenous variation in cortisol.Frontiers in psychology · 2025Article
- Sub-chronic stress exerts partially distinct behavioral and epigenetic effects in male and female mice.Frontiers in behavioral neuroscience · 2025Article
- No effects of acute stress on monetary delay discounting: A systematic literature review and meta-analysis.Neurobiology of stress · 2024Review
- Effects of acute stress on reward processing: A comprehensive meta-analysis of rodent and human studies.Neurobiology of stress · 2024Review
- Noradrenergic modulation of stress induced catecholamine release: Opposing influence of FG7142 and yohimbine.bioRxiv : the preprint server for biology · 2024Article
- Acute stress differentially alters reward-related decision making and inhibitory control under threat of punishment.Neurobiology of stress · 2024Review
- Choice impulsivity after repeated social stress is associated with increased perineuronal nets in the medial prefrontal cortex.Scientific reports · 2024Article
- A stress-sensitive frontostriatal circuit supporting effortful reward-seeking behavior.Neuron · 2024Article
- Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Acute stress can exert beneficial or detrimental effects on different forms of cognition. In the present study, we assessed the effects of acute restraint stress on different forms of cost/benefit decision-making, and some of the hormonal and neurochemical mechanisms that may underlie these effects. Effort-based decision-making was assessed where rats chose between a low effort/reward (1 press=2 pellets) or high effort/reward option (4 pellets), with the effort requirement increasing over 4 blocks of trials (2, 5, 10, and 20 lever presses). Restraint stress for 1 h decreased preference for the more costly reward and induced longer choice latencies. Control experiments revealed that the effects on decision-making were not mediated by general reductions in motivation or preference for larger rewards. In contrast, acute stress did not affect delay-discounting, when rats chose between a small/immediate vs larger/delayed reward. The effects of stress on decision-making were not mimicked by treatment with physiological doses of corticosterone (1-3 mg/kg). Blockade of dopamine receptors with flupenthixol (0.25 mg/kg) before restraint did not attenuate stress-induced effects on effort-related choice, but abolished effects on choice latencies. These data suggest that acute stress interferes somewhat selectively with cost/benefit evaluations concerning effort costs. These effects do not appear to be mediated solely by enhanced glucocorticoid activity, whereas dopaminergic activation may contribute to increased deliberation times induced by stress. These findings may provide insight into impairments in decision-making and anergia associated with stress-related disorders, such as depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.