ReviewCurrent opinion in ophthalmology2012
Trachoma: an update on prevention, diagnosis, and treatment.
Review in Current opinion in ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Active trachoma among children aged 1-9 years in Ethiopia: A meta-analysis from 2019 to 2024.PloS one · 2025Pooled it
- Acceptability and perceived utility of different diagnostic tests and sample types for trachoma surveillance in the Bijagos Islands, Guinea Bissau.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2021Article
- Mass Azithromycin Distribution and Community Microbiome: A Cluster-Randomized Trial.Open forum infectious diseases · 2018Article
- Replication-dependent size reduction precedes differentiation in Chlamydia trachomatis.Nature communications · 2018Article
- Optimal Proliferation and Differentiation ofStudies in applied mathematics (Cambridge, Mass.) · 2017Article
- Chlamydial eye infections: Current perspectives.Indian journal of ophthalmology · 2017Review
- Azithromycin for Malaria?The American journal of tropical medicine and hygiene · 2016Article
- Draft Genome Sequence of High-Temperature-Adapted Protochlamydia sp. HS-T3, an Amoebal Endosymbiotic Bacterium Found in Acanthamoeba Isolated from a Hot Spring in Japan.Genome announcements · 2015Article
- Article
- Host defense at the ocular surface.International reviews of immunology · 2013Review
- Will the SAFE strategy be sufficient to eliminate trachoma by 2020? Puzzlements and possible solutions.TheScientificWorldJournal · 2013Review
- An eye for azithromycin: review of the literature.Therapeutic advances in ophthalmologyReview
- A possible trachoma cluster unveiling the mist of Le Rôdeur: probes in favor and against an alternative cause of the crew blindness.Pathogens and global healthArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
purpose of reviewTo review recent clinical and epidemiological studies regarding the prevention, diagnosis, and treatment of trachoma. RECENT
findingsNewer studies propose novel diagnostic tests that appear sensitive for the detection of ocular chlamydial infection. For example, recent studies with ribosomal RNA-based nucleic acid amplification tests (NAATs) have demonstrated improved sensitivities compared to DNA-based NAATs; and the progression of scarring has now been characterized with confocal microscopy. Immunologic studies have further explored the etiology of clinical sequelae, suggesting that chronic inflammation can lead to progressive scarring even in the absence of Chlamydia. Mass oral azithromycin distributions remain a mainstay of treatment; studies have assessed the appropriate frequency and duration of treatment programs. Current studies have also explored ancillary effects of azithromycin distribution on mortality and bacterial infections. SUMMARY: Trachoma programs have had remarkable success at reducing chlamydial infection and clinical signs of trachoma. Recent work suggests improved methods to monitor infection and scarring, and better ways to distribute treatment. Whereas studies continue to demonstrate reduction in infection in hyperendemic areas, more work is necessary to achieve elimination of this blinding disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.