ArticleNature communications2012
Hydroxylation of 5-methylcytosine by TET2 maintains the active state of the mammalian HOXA cluster.
Article in Nature communications, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 72 citations in OpenAlex.
- Tet2 deficiency drives age-related heterogeneous progression of myeloid neoplasms through epigenetic-immune microenvironment imbalance.Journal of translational medicine · 2026Article
- The Association between Long-Term DDT or DDE Exposures and an Altered Sperm Epigenome-a Cross-Sectional Study of Greenlandic Inuit and South African VhaVenda Men.Environmental health perspectives · 2024Article
- Micronutrient regulation of the DNA methylome.Frontiers in epigenetics and epigenomics · 2024Review
- HOXA9 has the hallmarks of a biological switch with implications in blood cancers.Nature communications · 2022Article
- Effect of DNA modifications on the transition between canonical and non-canonical DNA structures in CpG islands during senescence.RSC advances · 2021Article
- Loss ofBlood science (Baltimore, Md.) · 2020Article
- The Pathobiology of Skin Aging: New Insights into an Old Dilemma.The American journal of pathology · 2020Review
- Reduced H3K27me3 leads to abnormal Hox gene expression in neural tube defects.Epigenetics & chromatin · 2019Article
- TET2 binding to enhancers facilitates transcription factor recruitment in hematopoietic cells.Genome research · 2019Article
- X-ray irradiation induces subtle changes in the genome-wide distribution of DNA hydroxymethylation with opposing trends in genic and intergenic regions.Epigenetics · 2019Article
- Molecular determinants of pathogenesis and clinical phenotype in myeloproliferative neoplasms.Haematologica · 2017Review
- Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Tet1 and Tet2 Protect DNA Methylation Canyons against Hypermethylation.Molecular and cellular biology · 2016Article
- DNA methylation profiling identifies novel markers of progression in hepatitis B-related chronic liver disease.Clinical epigenetics · 2016Article
- Epigenetic regulation of human adipose-derived stem cells differentiation.Molecular and cellular biochemistry · 2015Article
- Exploring the emerging complexity in transcriptional regulation of energy homeostasis.Nature reviews. Genetics · 2015Review
- Arterial endothelial methylome: differential DNA methylation in athero-susceptible disturbed flow regions in vivo.BMC genomics · 2015Article
- Establishing pluripotency in early development.Biochimica et biophysica acta · 2015Review
- The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.Nature cell biology · 2015Article
- Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond.Epigenetics & chromatin · 2015Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Differentiation is accompanied by extensive epigenomic reprogramming, leading to the repression of stemness factors and the transcriptional maintenance of activated lineage-specific genes. Here we use the mammalian Hoxa cluster of developmental genes as a model system to follow changes in DNA modification patterns during retinoic acid-induced differentiation. We find the inactive cluster to be marked by defined patterns of 5-methylcytosine (5mC). Upon the induction of differentiation, the active anterior part of the cluster becomes increasingly enriched in 5-hydroxymethylcytosine (5hmC), following closely the colinear activation pattern of the gene array, which is paralleled by the reduction of 5mC. Depletion of the 5hmC generating dioxygenase Tet2 impairs the maintenance of Hoxa activity and partially restores 5mC levels. Our results indicate that gene-specific 5mC-5hmC conversion by Tet2 is crucial for the maintenance of active chromatin states at lineage-specific loci.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.