ArticleEnvironmental health perspectives2012
Plasmid-mediated quinolone resistance genes and antibiotic residues in wastewater and soil adjacent to swine feedlots: potential transfer to agricultural lands.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed, 145 citations in OpenAlex.
- Age- and diet-driven assembly of the gut antibiotic resistome in humans and food-producing animals.Gut microbes · 2026Review
- CRISPR Technology Applied to the Analysis of Antibiotic Resistance Genes in the Environment.Environment & health (Washington, D.C.) · 2026Review
- Effects of Inorganic Fluoride and the Fluoroquinolone Antibiotic Pefloxacin on the Growth and Microbiome Structure ofInternational journal of molecular sciences · 2026Article
- Environmental fate of antibiotic resistance genes in livestock farming.Archives of microbiology · 2025Review
- 2002-2022 Quinolone Resistance inVeterinary sciences · 2025Review
- Comprehensive Study of Antibiotics and Antibiotic Resistance Genes in Wastewater and Impacted Mediterranean Water Environments.Antibiotics (Basel, Switzerland) · 2025Article
- Sample Preparation Approaches for Determination of Quinolones in Aqueous Matrixes: Systematic Review.ACS measurement science au · 2025Review
- Comprehensive Study of Antibiotic Resistance inAntibiotics (Basel, Switzerland) · 2024Article
- Drivers of Antibiotic Resistance Gene Abundance in an Urban River.Antibiotics (Basel, Switzerland) · 2023Article
- High Carriage Rate of the Multiple Resistant Plasmids Harboring Quinolone Resistance Genes inAntibiotics (Basel, Switzerland) · 2021Article
- Occurrence and removal of antibiotics, antibiotic resistance genes, and bacterial communities in hospital wastewater.Environmental science and pollution research international · 2021Article
- Phenotypic and Genotypic Properties of Fluoroquinolone-Resistant,Microorganisms · 2021Article
- Impact factors of the accumulation, migration and spread of antibiotic resistance in the environment.Environmental geochemistry and health · 2021Review
- Changes in Antibiotic Resistance Gene Levels in Soil after Irrigation with Treated Wastewater: A Comparison between Heterogeneous Photocatalysis and Chlorination.Environmental science & technology · 2020Article
- Visible-light-driven CQDs@MIL-125(Ti) nanocomposite photocatalyst with enhanced photocatalytic activity for the degradation of tetracycline.RSC advances · 2019Article
- Prevalence of Antibiotic Resistance Genes in Multidrug-ResistantAntibiotics (Basel, Switzerland) · 2019Article
- Investigation of antibiotics in sea cucumbers: occurrence, pollution characteristics, and human risk assessment.Environmental science and pollution research international · 2018Article
- Antibiotic resistance genes in China: occurrence, risk, and correlation among different parameters.Environmental science and pollution research international · 2018Review
- The Prevalence of Plasmid-mediated Quinolone Resistance Genes inIranian journal of public health · 2017Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInappropriate use of antibiotics in swine feed could cause accelerated emergence of antibiotic resistance genes, and agricultural application of swine waste could spread antibiotic resistance genes to the surrounding environment.
objectivesWe investigated the distribution of plasmid-mediated quinolone resistance (PMQR) genes from swine feedlots and their surrounding environment.
methodsWe used a culture-independent method to identify PMQR genes and estimate their levels in wastewater from seven swine feedlot operations and corresponding wastewater-irrigated farm fields. Concentrations of (fluoro)quinolones in wastewater and soil samples were determined by ultra-performance liquid chromatography-electrospray tandem mass spectrometry.
resultsThe predominant PMQR genes in both the wastewater and soil samples were qnrD, qepA, and oqxB, whereas qnrS and oqxA were present only in wastewater samples. Absolute concentrations of all PMQR genes combined ranged from 1.66 × 107 to 4.06 × 108 copies/mL in wastewater and 4.06 × 106 to 9.52 × 107 copies/g in soil. Concentrations of (fluoro)quinolones ranged from 4.57 to 321 ng/mL in wastewater and below detection limit to 23.4 ng/g in soil. Significant correlations were found between the relative abundance of PMQR genes and (fluoro)quinolone concentrations (r = 0.71, p = 0.005) and the relative abundance of PMQR genes in paired wastewater and agricultural soil samples (r = 0.91, p = 0.005).
conclusionsSwine feedlot wastewater may be a source of PMQR genes that could facilitate the spread of antibiotic resistance. To our knowledge, this is the first study to examine the occurrence of PMQR genes in animal husbandry environments using a culture-independent method.
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