ReviewCell adhesion & migration
Crossroads of integrins and cadherins in epithelia and stroma remodeling.
Review in Cell adhesion & migration. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Mechanical Regulation of Oral Epithelial Barrier Function.Bioengineering (Basel, Switzerland) · 2023Article
- p63-related signaling at a glance.Journal of cell science · 2020Review
- Interplay between cadherins and α2β1 integrin differentially regulates melanoma cell invasion.British journal of cancer · 2015Article
- p120-catenin differentially regulates cell migration by Rho-dependent intracellular and secreted signals.EMBO reports · 2014Article
- The integrin β1 subunit regulates paracellular permeability of kidney proximal tubule cells.The Journal of biological chemistry · 2014Article
- Plakophilin 2 affects cell migration by modulating focal adhesion dynamics and integrin protein expression.The Journal of investigative dermatology · 2014Article
- Host matrix modulation by tumor exosomes promotes motility and invasiveness.Neoplasia (New York, N.Y.) · 2013Article
- Immunohistochemical expression of paxillin in ameloblastoma and odontogenic keratocyst: An observational study.Journal of oral and maxillofacial pathology : JOMFPReview
- Immunohistochemical expression of paxillin in potentially malignant disorders and squamous cell carcinoma patients.Journal of oral and maxillofacial pathology : JOMFPArticle
- Tumor microenvironment indoctrination: an emerging hallmark of cancer.Cell adhesion & migrationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesion events mediated by cadherin and integrin adhesion receptors have fundamental roles in the maintenance of the physiological balance of epithelial tissues, and it is well established that perturbations in their normal functional activity and/or changes in their expression are associated with tumorigenesis. Over the last decades, increasing evidence of a dynamic collaborative interaction between these complexes through their shared interactions with cytoskeletal proteins and common signaling pathways has emerged not only as an important regulator of several aspects of epithelial cell behavior, but also as a coordinated adhesion module that senses and transmits signals from and to the epithelia surrounding microenvironment. The tight regulation of their crosstalk is particularly important during epithelial remodeling events that normally take place during morphogenesis and tissue repair, and when defective it leads to cell transformation and aggravated responses of the tumor microenvironment that contribute to tumorigenesis. In this review we highlight some of the interactions that regulate their crosstalk and how this could be implicated in regulating signals across epithelial tissues to sustain homeostasis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.