ArticleBMC genomics2012
Construction of physical maps for the sex-specific regions of papaya sex chromosomes.
Article in BMC genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Morphological Staging and Transcriptomic Analyses Reveal Divergent Reproductive Organ Fates in Papaya Flowers.Plants (Basel, Switzerland) · 2026Article
- Identification and molecular analysis of the Y-specific CpMp gene controlling long male peduncles in papaya.Nature communications · 2025Article
- Complementing model species with model clades.The Plant cell · 2024Review
- Descriptive Genomic Analysis and Sequence Genotyping of the Two Papaya Species (Vasconcellea pubescens and Vasconcellea chilensis) Using GBS Tools.Plants (Basel, Switzerland) · 2022Article
- SunUp and Sunset genomes revealed impact of particle bombardment mediated transformation and domestication history in papaya.Nature genetics · 2022Article
- The Sister Chromatid Division of the Heteromorphic Sex Chromosomes inInternational journal of molecular sciences · 2022Article
- Genomic characterization of a rare Carica papaya X chromosome mutant reveals a candidate monodehydroascorbate reductase 4 gene involved in all-hermaphrodite phenomenon.Molecular genetics and genomics : MGG · 2021Article
- The Diversity of Plant Sex Chromosomes Highlighted through Advances in Genome Sequencing.Genes · 2021Review
- Article
- Genetic Diversity on the Sex Chromosomes.Genome biology and evolution · 2018Review
- Extremely low nucleotide diversity in the X-linked region of papaya caused by a strong selective sweep.Genome biology · 2016Article
- A polymorphic pseudoautosomal boundary in the Carica papaya sex chromosomes.Molecular genetics and genomics : MGG · 2015Article
- Genome sequence comparison reveals a candidate gene involved in male-hermaphrodite differentiation in papaya (Carica papaya) trees.Molecular genetics and genomics : MGG · 2015Article
- Evidence for emergence of sex-determining gene(s) in a centromeric region in Vasconcellea parviflora.Genetics · 2015Article
- Flower development, pollen fertility and sex expression analyses of three sexual phenotypes of Coccinia grandis.BMC plant biology · 2014Article
- Accumulation of interspersed and sex-specific repeats in the non-recombining region of papaya sex chromosomes.BMC genomics · 2014Article
- Genetics of dioecy and causal sex chromosomes in plants.Journal of genetics · 2014Review
- Sex specific expression and distribution of small RNAs in papaya.BMC genomics · 2014Article
- Construction and characterization of a BAC library from the Coffea arabica genotype Timor Hybrid CIFC 832/2.Genetica · 2013Article
- Organelle DNA accumulation in the recently evolved papaya sex chromosomes.Molecular genetics and genomics : MGG · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 8 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPapaya is a major fruit crop in tropical and subtropical regions worldwide. It is trioecious with three sex forms: male, female, and hermaphrodite. Sex determination is controlled by a pair of nascent sex chromosomes with two slightly different Y chromosomes, Y for male and Yh for hermaphrodite. The sex chromosome genotypes are XY (male), XYh (hermaphrodite), and XX (female). The papaya hermaphrodite-specific Yh chromosome region (HSY) is pericentromeric and heterochromatic. Physical mapping of HSY and its X counterpart is essential for sequencing these regions and uncovering the early events of sex chromosome evolution and to identify the sex determination genes for crop improvement.
resultsA reiterate chromosome walking strategy was applied to construct the two physical maps with three bacterial artificial chromosome (BAC) libraries. The HSY physical map consists of 68 overlapped BACs on the minimum tiling path, and covers all four HSY-specific Knobs. One gap remained in the region of Knob 1, the only knob structure shared between HSY and X, due to the lack of HSY-specific sequences. This gap was filled on the physical map of the HSY corresponding region in the X chromosome. The X physical map consists of 44 BACs on the minimum tiling path with one gap remaining in the middle, due to the nature of highly repetitive sequences. This gap was filled on the HSY physical map. The borders of the non-recombining HSY were defined genetically by fine mapping using 1460 F2 individuals. The genetically defined HSY spanned approximately 8.5 Mb, whereas its X counterpart extended about 5.4 Mb including a 900 Kb region containing the Knob 1 shared by the HSY and X. The 8.5 Mb HSY corresponds to 4.5 Mb of its X counterpart, showing 4 Mb (89%) DNA sequence expansion.
conclusionThe 89% increase of DNA sequence in HSY indicates rapid expansion of the Yh chromosome after genetic recombination was suppressed 2-3 million years ago. The genetically defined borders coincide with the common BACs on the minimum tiling paths of HSY and X. The minimum tiling paths of HSY and its X counterpart are being used for sequencing these X and Yh-specific regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.