ArticleOphthalmic epidemiology2012
Retinal microvascular abnormalities and cognitive function in Latino adults in Los Angeles.
Article in Ophthalmic epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.
- Associations between retinal microvascular changes and dementia, cognitive functioning, and brain imaging abnormalities: a systematic review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Pooled it
- Retinal Microvasculature Changes Linked to Executive Function Impairment after COVID-19.Journal of clinical medicine · 2024Article
- Prognostic potentials of AI in ophthalmology: systemic disease forecasting via retinal imaging.Eye and vision (London, England) · 2024Review
- Macular vessel density in the superficial plexus is not a proxy of cerebrovascular damage in non-demented individuals: data from the NORFACE cohort.Alzheimer's research & therapy · 2024Article
- Retinal vessel caliber and cognitive performance: the multi-ethnic study of atherosclerosis (MESA).Scientific reports · 2024Article
- Association of Central Retinal Arteriolar and Venular Equivalents with Brain-aging and Macular Ganglion Cell-inner Plexiform Layer Thickness.Ophthalmic epidemiology · 2023Article
- Neurovascular coupling unit dysfunction and dementia: Retinal measurements as tools to move towards population-based evidence.Frontiers in endocrinology · 2022Review
- Deep-learning retinal vessel calibre measurements and risk of cognitive decline and dementia.Brain communications · 2022Article
- Relationship between Retinal Microvasculature, Cardiovascular Risk and Silent Brain Infarction in Hypertensive Patients.Diagnostics (Basel, Switzerland) · 2021Article
- Retinal microvascular parameters are not significantly associated with mild cognitive impairment in the Northern Ireland Cohort for the Longitudinal Study of Ageing.BMC neurology · 2021Article
- Lower retinal capillary density in minimal cognitive impairment among older Latinx adults.Alzheimer's & dementia (Amsterdam, Netherlands) · 2020Article
- Association between Retinal Vascular Geometric Changes and Cognitive Impairment: A Systematic Review and Meta-Analysis.Journal of clinical neurology (Seoul, Korea) · 2020Article
- Cognitive Function and Ophthalmological Diseases: The Beijing Eye Study.Scientific reports · 2018Article
- Potential Utility of Retinal Imaging for Alzheimer's Disease: A Review.Frontiers in aging neuroscience · 2018Review
- Retinal microvascular network alterations: potential biomarkers of cerebrovascular and neural diseases.American journal of physiology. Heart and circulatory physiology · 2017Review
- Retinal vascular fractals and cognitive impairment.Dementia and geriatric cognitive disorders extra · 2014Article
- Prevalence and risk factors of idiopathic epiretinal membranes in Beixinjing blocks, Shanghai, China.PloS one · 2012Article
- Cognitive abilities screening instrument-short form, mini-mental state examination and functional activities questionnaire in the illiterate elderly.Dementia & neuropsychologiaArticle
- [Reliability of retinography for the detection of hypertensive retinopathy in Primary Care].Atencion primariaArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeRetinal vessels may provide a readily accessible surrogate approach to study vascular disease in brain small vessels. Previous epidemiologic studies of retinal microvascular abnormalities and cognition have not included large numbers of Latinos who have a high prevalence of diabetes and hypertension.
methodsWe used data from 809 elderly Latino participants in the Los Angeles Latino Eye Study (LALES) to assess whether retinal vessel caliber and microvascular abnormalities are cross-sectionally associated with lower cognitive function. Cognitive screening was conducted with the Cognitive Abilities Screening Instrument-Short form (CASI-S) and in-depth testing with the Spanish English Neuropsychological Assessment Scales (SENAS). Retinal photographs were used to identify retinopathy signs and measure retinal vessel caliber.
resultsA total of 65.8% had high blood pressure, 34.5% had diabetes; self-reported diagnoses of heart attack, heart failure, angina and stroke were rare. Retinal calibers and any retinopathy were not associated with the CASI-S, total SENAS or any SENAS cognitive factors assessed as continuous variables. The odds of a low CASI-S score were two times higher in subjects with generalized arteriolar narrowing (OR = 2.04, 95% CI = 1.14, 3.66), and one and half times as high in those with both generalized arteriolar narrowing and retinopathy signs (OR = 1.49, 95% CI = 0.47, 4.75) though this result was based on only four cases with both risk factors and confidence limits were wide and included the null.
conclusionRetinal microvasculature imaging may provide insights into small blood vessel influences on cognition in Latino populations. Additional studies in diverse populations and prospective settings are needed.
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Registered trials
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