ArticleJournal of the American Geriatrics Society2012
Antidepressant use, depressive symptoms, and incident frailty in women aged 65 and older from the Women's Health Initiative Observational Study.
Article in Journal of the American Geriatrics Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 4 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Association between Drug Therapy and Risk of Incident Frailty: A Systematic Review.Annals of geriatric medicine and research · 2024Pooled it
- The Frail Depressed Patient: A Narrative Review on Treatment Challenges.Clinical interventions in aging · 2022Pooled it
- Pooled it
- Depression and frailty in later life: a systematic review.Clinical interventions in aging · 2015Pooled it
- Medication Use by Older Adults with Frailty: A Scoping Review.Pharmacy (Basel, Switzerland) · 2025Review
- Analysis of Frailty Indices Based on Sociodemographic and Clinical Determinants in Older Women.Healthcare (Basel, Switzerland) · 2025Article
- Coexisting frailty and depression associated with low physical activity and quality of life in Saudi community-dwelling older adults: a cross-sectional study.Frontiers in public health · 2025Article
- Relationship of psychotropic medication use with physical function among postmenopausal women.GeroScience · 2024Article
- Article
- Depressive symptoms and antidepressant use in relation to white blood cell count among postmenopausal women from the Women's Health Initiative.Translational psychiatry · 2024Article
- Predictors of incident reversible and potentially reversible cognitive frailty among Taiwanese older adults.BMC geriatrics · 2023Article
- Associations of poor sleep quality, chronic pain and depressive symptoms with frailty in older patients: is there a sex difference?BMC geriatrics · 2022Article
- Prevalence of Frailty and Its Association with Depressive Symptoms among European Older Adults from 17 Countries: A 5-Year Longitudinal Study.International journal of environmental research and public health · 2022Article
- A novel set of volatile urinary biomarkers for late-life major depressive and anxiety disorders upon the progression of frailty: a pilot study.Discover mental health · 2022Article
- An Interpretable Machine Learning Approach to Predict Fall Risk Among Community-Dwelling Older Adults: a Three-Year Longitudinal Study.Journal of general internal medicine · 2022Article
- The transitions and predictors of cognitive frailty with multi-state Markov model: a cohort study.BMC geriatrics · 2022Article
- Bidirectional Longitudinal Study of Frailty and Depressive Symptoms Among Older Chinese Adults.Frontiers in aging neuroscience · 2022Article
- Frailty, aging, and periodontal disease: Basic biologic considerations.Periodontology 2000 · 2021Review
- Guidance for appropriate use of psychotropic drugs in older people.European geriatric medicine · 2021Review
- Frailty in relation to psycho-social factors in elderly patients with rheumatoid arthritis: A cross-sectional mixed qualitative-quantitative study.International journal of rheumatic diseases · 2021Article
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Authors and funding
13 authors at 10 institutions in 1 country.
Funding
Abstract
objectivesTo examine the associations between depressive symptoms, antidepressant use, and duration of use with incident frailty 3 years later in nonfrail women aged 65 and older.
designSecondary analysis of the Women's Health Initiative Observational Study (WHI-OS), a prospective cohort study.
settingWHI-OS was conducted in 40 U.S. clinical centers.
participantsWomen aged 65 to 79, not frail at baseline. MEASUREMENTS: Antidepressant use was assessed through medication container inspection at baseline. Four groups were created according to baseline use and Burnam depression screen (range 0-1, 0.06 cutoff): antidepressant nonusers without depressive symptoms (reference group), antidepressant nonusers with depressive symptoms, antidepressant users without depressive symptoms, and antidepressant users with depressive symptoms. Frailty components included slowness or weakness, exhaustion, low physical activity, and unintended weight loss, ascertained through self-report and physical measurements at baseline and Year 3.
resultsOf 27,652 women at baseline, 1,350 (4.9%) were antidepressant users and 1,794 (6.5%) were categorized as depressed. At Year 3, 4,125 (14.9%) were frail. All groups had a greater risk of incident frailty than the reference group. Odds ratios (ORs) ranged from 1.73 (95% confidence interval (CI) = 1.41-2.12) in antidepressant users who were not depressed to 3.63 in antidepressant users who were depressed (95% CI = 2.37-5.55). All durations of use were associated with incident frailty (<1 year OR = 1.95, 95% CI = 1.41-2.68; 1-3 years OR = 1.99, 95% CI = 1.45-2.74; >3 years OR = 1.60, 95% CI = 1.20-2.14).
conclusionIn older adult women, depressive symptoms and antidepressant use were associated with frailty after 3 years of follow-up.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.