Evidence map›Paper›PMID 22567597›Full record

ArticleBiomedical optics express2012

In vivo imaging of unstained tissues using long gradient index lens multiphoton endoscopic systems.

David M Huland, Christopher M Brown, Scott S Howard, Dimitre G Ouzounov, Ina Pavlova, Ke Wang, David R Rivera, Watt W Webb, Chris Xu

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 125 citations in OpenAlex.

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  15. Label-Free Multiphoton Endomicroscopy for Minimally Invasive In Vivo Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

David M Huland
Christopher M Brown
Scott S Howard
Dimitre G Ouzounov
Ina Pavlova
Ke Wang
David R Rivera
Watt W Webb
Chris Xu
Cornell University · US

Funding

Development of Medical Multiphoton Microscopic EndoscopyR01EB006736 · NIBIB · CORNELL UNIVERSITY · PI WEBB, WATT W · 2007 to 2011
$5.3M
Academic-industrial partnership for development of in vivo imaging systems and meR01CA133148 · NCI · CORNELL UNIVERSITY · PI GRUNER-NIELSEN, LARS, XU, CHRIS · 2008 to 2011
$1.8M
NCI NIH HHS R01 CA133148NIBIB NIH HHS R01 EB006736
6 · The paper itself

Abstract

We characterize long (up to 285 mm) gradient index (GRIN) lens endoscope systems for multiphoton imaging. We fabricate a portable, rigid endoscope system suitable for imaging unstained tissues, potentially deep within the body, using a GRIN lens system of 1 mm diameter and 8 cm length. The portable device is capable of imaging a ~200 µm diameter field of view at 4 frames/s. The lateral and axial resolution in water is 0.85 µm and 7.4 µm respectively. In vivo images of unstained tissues in live, anesthetized rats using the portable device are presented. These results show great promise for GRIN endoscopy to be used clinically.

Indexed as

(110.2760) Gradient-index lenses(170.2150) Endoscopic imaging(180.4315) Nonlinear microscopy

Identifiers

PMID22567597
PMCPMC3342183
OpenAlexW2053691751

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.