ArticleGenetics research international2011
Molecular aspects of breast cancer metastasis to the brain.
Article in Genetics research international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- SRRM4-mediated REST to REST4 dysregulation promotes tumor growth and neural adaptation in breast cancer leading to brain metastasis.Neuro-oncology · 2024Article
- The Potential Role of Exosomes in the Treatment of Brain Tumors, Recent Updates and Advances.Frontiers in oncology · 2022Review
- Astrocytic IGFBP2 and CHI3L1 in cerebrospinal fluid drive cortical metastasis of HER2+breast cancer.Clinical & experimental metastasis · 2020Article
- Clinical Perspectives in Brain Metastasis.Cold Spring Harbor perspectives in medicine · 2020Review
- Identification of breast cancer patients with a high risk of developing brain metastases: a single-institutional retrospective analysis.BMC cancer · 2014Article
- Risk factors and survival outcome in cerebral metastatic breast cancer.Medical oncology (Northwood, London, England) · 2014Article
- Multimodal imaging enables early detection and characterization of changes in tumor permeability of brain metastases.Journal of controlled release : official journal of the Controlled Release Society · 2013Article
- Receptor change-clinicopathologic analysis of matched pairs of primary and cerebral metastatic breast cancer.Journal of cancer research and clinical oncology · 2013Article
- CNS metastases of breast cancer show discordant immunohistochemical phenotype compared to primary.Journal of cancer research and clinical oncology · 2013Article
- Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our knowledge of the biology underlying the development of brain metastases (BM) from breast cancer has improved over the last decade due to large clinical epidemiological studies, animal models of metastasis, and the use of high-resolution gene expression profiling technologies. However, there are still major gaps in our understanding of the mechanisms utilized by breast cancer cells to colonize the brain microenvironment, thus our arsenal of therapies remains relatively nonspecific, and the prognosis for breast cancer patients with BM remains poor. Additional insights into these mechanisms are necessary to facilitate the development of new preventive and curative therapeutic regimens to block this fatal disease. This paper aims to provide a general overview for the readers of what has been achieved in this field of research and its translation into clinical practice to date and to highlight exciting new areas of research that promise to inform the development of new targeted therapies for BM.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.