ArticlePloS one2012
Identification of QTL for UV-protective eye area pigmentation in cattle by progeny phenotyping and genome-wide association analysis.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 57 citations in OpenAlex.
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- Bovine Ocular Squamous Cell Carcinoma-A Descriptive Epidemiological Survey in the Azores, Portugal.Veterinary sciences · 2026Article
- Genotype imputation performance in Nellore cattle across different SNP panels and software tools.Tropical animal health and production · 2026Article
- Beyond black and white: dissecting the genetic basis of skin depigmentation in Nellore cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2025Article
- Exploring genomic signatures of selection for adaptation and resilience in nomadic Belahi cattle in the tropical climate.Molecular biology reports · 2025Article
- Genetic Diversity, Admixture, and Selection Signatures in a Rarámuri Criollo Cattle Population Introduced to the Southwestern United States.International journal of molecular sciences · 2025Article
- Taurine pangenome uncovers a segmental duplication upstream ofGenome research · 2025Article
- Genomic patterns of selection in morphometric traits across diverse Indian cattle breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2024Article
- Genome-Wide Association Analysis Identifies theAnimals : an open access journal from MDPI · 2023Article
- Uncovering genes underlying coat color variation in indigenous cattle breeds through genome-wide positive selection.Animal biotechnology · 2023Article
- Whole Genome Resequencing Reveals Selection Signals Related to Wool Color in Sheep.Animals : an open access journal from MDPI · 2023Article
- Revealing the genetic basis of eyelid pigmentation in Hereford cattle.Journal of animal science · 2022Article
- Identification of Long Noncoding RNAs Involved in Eyelid Pigmentation of Hereford Cattle.Frontiers in genetics · 2022Article
- Integrative QTL mapping and selection signatures in Groningen White Headed cattle inferred from whole-genome sequences.PloS one · 2022Article
- Genome-Wide Scanning for Signatures of Selection Revealed the Putative Genomic Regions and Candidate Genes Controlling Milk Composition and Coat Color Traits in Sahiwal Cattle.Frontiers in genetics · 2021Article
- Minimal Erythema Dose Determination in Holstein Friesian Cattle.Frontiers in veterinary science · 2021Article
- Genomic Characteristics and Selection Signatures in Indigenous Chongming White Goat (Frontiers in genetics · 2020Article
- Comparative genome analyses reveal the unique genetic composition and selection signals underlying the phenotypic characteristics of three Chinese domestic goat breeds.Genetics, selection, evolution : GSE · 2019Article
- Genome-wide association analysis reveals QTL and candidate mutations involved in white spotting in cattle.Genetics, selection, evolution : GSE · 2019Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pigmentation patterns allow for the differentiation of cattle breeds. A dominantly inherited white head is characteristic for animals of the Fleckvieh (FV) breed. However, a minority of the FV animals exhibits peculiar pigmentation surrounding the eyes (ambilateral circumocular pigmentation, ACOP). In areas where animals are exposed to increased solar ultraviolet radiation, ACOP is associated with a reduced susceptibility to bovine ocular squamous cell carcinoma (BOSCC, eye cancer). Eye cancer is the most prevalent malignant tumour affecting cattle. Selection for animals with ACOP rapidly reduces the incidence of BOSCC. To identify quantitative trait loci (QTL) underlying ACOP, we performed a genome-wide association study using 658,385 single nucleotide polymorphisms (SNPs). The study population consisted of 3579 bulls of the FV breed with a total of 320,186 progeny with phenotypes for ACOP. The proportion of progeny with ACOP was used as a quantitative trait with high heritability (h(2) = 0.79). A variance component based approach to account for population stratification uncovered twelve QTL regions on seven chromosomes. The identified QTL point to MCM6, PAX3, ERBB3, KITLG, LEF1, DKK2, KIT, CRIM1, ATRN, GSDMC, MITF and NBEAL2 as underlying genes for eye area pigmentation in cattle. The twelve QTL regions explain 44.96% of the phenotypic variance of the proportion of daughters with ACOP. The chromosomes harbouring significantly associated SNPs account for 54.13% of the phenotypic variance, while another 19.51% of the phenotypic variance is attributable to chromosomes without identified QTL. Thus, the missing heritability amounts to 7% only. Our results support a polygenic inheritance pattern of ACOP in cattle and provide the basis for efficient genomic selection of animals that are less susceptible to serious eye diseases.
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