ArticlePloS one2012
Riboflavin ameliorates cisplatin induced toxicities under photoillumination.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
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- Effect of Naringenin on Potassium Bromate-Induced Hepatotoxicity In Vivo: A Dose-Dependent Study.Journal of applied toxicology : JAT · 2025Article
- Improving cisplatin chemotherapy in vivo by niosomal propolis and chrysin as nanoadjuvants.Medical oncology (Northwood, London, England) · 2025Article
- The Preventive Effect of Zinc Sulfate against Olanzapine-Induced Testicular Toxicity in Male Rats.Biological trace element research · 2025Article
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- Zinc Oxide Nanoparticles Blunt Potassium-Bromate-Induced Renal Toxicity by Reinforcing the Redox System.Molecules (Basel, Switzerland) · 2023Article
- Some Natural Photosensitizers and Their Medicinal Properties for Use in Photodynamic Therapy.Molecules (Basel, Switzerland) · 2022Review
- Bioactive Tryptophan-Based Copper Complex with Auxiliary β-Carboline Spectacle Potential on Human Breast Cancer Cells: In Vitro and In Vivo Studies.Molecules (Basel, Switzerland) · 2021Article
- Chemopreventive effect of riboflavin on the potassium bromate-induced renal toxicity in vivo.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- The effect of some natural antioxidants against cisplatin-induced neurotoxicity in rats: behavioral testing.Heliyon · 2020Article
- The Alleviative Effect of Vitamin BBioMed research international · 2020Article
- Diabetes-Mediated Toxicity Resulted in the Expression of CD80 and CD86 on Neutrophils after Delayed Wound Healing in Male Rats.BioMed research international · 2020Article
- Ameliorative effect of zinc oxide nanoparticles against potassium bromate-mediated toxicity in Swiss albino rats.Environmental science and pollution research international · 2019Article
- Efficacy of a Methanolic Extract ofBioMed research international · 2019Article
- Biosynthesized Silver Nanoparticle (AgNP) FromFrontiers in microbiology · 2019Article
- Ameliorative effects of rutin against cisplatin-induced reproductive toxicity in male rats.BMC urology · 2018Article
- Potential effects of the combination of nicotinamide, vitamin B2 and vitamin C on oxidative-mediated hepatotoxicity induced by thioacetamide.Lipids in health and disease · 2018Article
- Restrained management of copper level enhances the antineoplastic activity of imatinib in vitro and in vivo.Scientific reports · 2018Article
- Targeting increased copper levels in diethylnitrosamine induced hepatocellular carcinoma cells in rats by epigallocatechin-3-gallate.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
- Calcitriol induced redox imbalance and DNA breakage in cells sharing a common metabolic feature of malignancies: Interaction with cellular copper (II) ions leads to the production of reactive oxygen species.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCisplatin is an effective anticancer drug that elicits many side effects mainly due to induction of oxidative and nitrosative stresses during prolonged chemotherapy. The severity of these side effects consequently restricts its clinical use under long term treatment. Riboflavin is an essential vitamin used in various metabolic redox reactions in the form of flavin adenine dinucleotide and flavin mononucleotide. Besides, it has excellent photosensitizing property that can be used to ameliorate these toxicities in mice under photodynamic therapy. METHODS AND
findingsRiboflavin, cisplatin and their combinations were given to the separate groups of mice under photoilluminated condition under specific treatment regime. Their kidney and liver were excised for comet assay and histopathological studies. Furthermore, Fourier Transform Infrared Spectroscopy of riboflavin-cisplatin combination in vitro was also conducted to investigate any possible interaction between the two compounds. Their comet assay and histopathological examination revealed that riboflavin in combination with cisplatin was able to protect the tissues from cisplatin induced toxicities and damages. Moreover, Fourier Transform Infrared Spectroscopy analysis of the combination indicated a strong molecular interaction among their constituent groups that may be assigned for the protective effect of the combination in the treated animals.
conclusionInclusion of riboflavin diminishes cisplatin induced toxicities which may possibly make the cisplatin-riboflavin combination, an effective treatment strategy under chemoradiotherapy in pronouncing its antineoplastic activity and sensitivity towards the cancer cells as compared to cisplatin alone.
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