ArticleBiomicrofluidics2012
An integrated, multiparametric flow cytometry chip using "microfluidic drifting" based three-dimensional hydrodynamic focusing.
Article in Biomicrofluidics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 110 citations in OpenAlex.
- Integrated microfluidic biosensors: shaping the future of quantitative life sciences and on-chip molecular diagnostics.Lab on a chip · 2026Review
- A low-cost, label-free microfluidic scanning flow cytometer for high-accuracy quantification of size and refractive index of particles.Lab on a chip · 2023Article
- Multi-color flow cytometer with PIC-based structured illumination.Biomedical optics express · 2022Article
- Backscattering-Based Discrimination of Microparticles Using an Optofluidic Multiangle Scattering Chip.ACS omega · 2022Article
- Massive image-based single-cell profiling reveals high levels of circulating platelet aggregates in patients with COVID-19.Nature communications · 2021Article
- A microfluidic flow analyzer with integrated lensed optical fibers.Biomicrofluidics · 2020Article
- Disease diagnostics using hydrodynamic flow focusing in microfluidic devices: Beyond flow cytometry.Biomedical engineering letters · 2020Review
- 3D Hydrodynamic Focusing in Microscale Optofluidic Channels Formed with a Single Sacrificial Layer.Micromachines · 2020Article
- Optofluidic detection setup for multi-parametric analysis of microbiological samples in droplets.Biomicrofluidics · 2020Article
- A cartridge based Point-of-Care device for complete blood count.Scientific reports · 2019Article
- Cell Cytometry: Review and Perspective on Biotechnological Advances.Frontiers in bioengineering and biotechnology · 2019Review
- Microfluidic flow cytometry: The role of microfabrication methodologies, performance and functional specification.Technology · 2018Article
- Sheathless Microflow Cytometry Using Viscoelastic Fluids.Scientific reports · 2017Article
- On-chip wireless silicon photonics: from reconfigurable interconnects to lab-on-chip devices.Light, science & applications · 2017Article
- Optofluidic device for the quantification of circulating tumor cells in breast cancer.Scientific reports · 2017Article
- Microfluidic cytometers with integrated on-chip optical systems for red blood cell and platelet counting.Biomicrofluidics · 2016Article
- A Microflow Cytometer with a Rectangular Quasi-Flat-Top Laser Spot.Sensors (Basel, Switzerland) · 2016Article
- Using binary optical elements (BOEs) to generate rectangular spots for illumination in micro flow cytometer.Biomicrofluidics · 2016Article
- A Microfluidic Approach for Inducing Cell Rotation by Means of Hydrodynamic Forces.Sensors (Basel, Switzerland) · 2016Article
- Acoustofluidic Transfer of Inflammatory Cells from Human Sputum Samples.Analytical chemistry · 2016Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
In this work, we demonstrate an integrated, single-layer, miniature flow cytometry device that is capable of multi-parametric particle analysis. The device integrates both particle focusing and detection components on-chip, including a "microfluidic drifting" based three-dimensional (3D) hydrodynamic focusing component and a series of optical fibers integrated into the microfluidic architecture to facilitate on-chip detection. With this design, multiple optical signals (i.e., forward scatter, side scatter, and fluorescence) from individual particles can be simultaneously detected. Experimental results indicate that the performance of our flow cytometry chip is comparable to its bulky, expensive desktop counterpart. The integration of on-chip 3D particle focusing with on-chip multi-parametric optical detection in a single-layer, mass-producible microfluidic device presents a major step towards low-cost flow cytometry chips for point-of-care clinical diagnostics.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.