ArticleExperimental diabetes research2012
Severe maternal hyperglycemia exacerbates the development of insulin resistance and fatty liver in the offspring on high fat diet.
Article in Experimental diabetes research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 29 citations in OpenAlex.
- lncRNA‑miRNA‑mRNA network in female offspring born from obese dams.Experimental and therapeutic medicine · 2023Article
- Severe gestational diabetes mellitus in lean dams is associated with low IL-1α levels and affects the growth of the juvenile mouse offspring.Scientific reports · 2023Article
- Long-term outcomes and potential mechanisms of offspring exposed to intrauterine hyperglycemia.Frontiers in nutrition · 2023Review
- Article
- Pregestational diet transition to normal-fat diet avoids the deterioration of pancreatic β-cell function in male offspring induced by maternal high-fat diet.The Journal of nutritional biochemistry · 2020Article
- Intergenerational Transmission of Diet-Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice.Arthritis & rheumatology (Hoboken, N.J.) · 2020Article
- Hyperglycemia During Pregnancy and Long-Term Offspring Outcomes.Current diabetes reports · 2019 · on this mapReview
- Neonatal overfeeding in mice aggravates the development of methionine and choline-deficient diet-induced steatohepatitis in adulthood.Genes & diseases · 2019Article
- CMHX008, a PPARγ partial agonist, enhances insulin sensitivity with minor influences on bone loss.Genes & diseases · 2018Article
- Maternal use of flaxseed oil during pregnancy and lactation prevents morphological alterations in pancreas of female offspring from rat dams with experimental diabetes.International journal of experimental pathology · 2015Article
- Critical periods of increased fetal vulnerability to a maternal high fat diet.Reproductive biology and endocrinology : RB&E · 2014Article
- Early life factors and type 2 diabetes mellitus.Journal of diabetes research · 2013Review
- Maternal rat diabetes mellitus deleteriously affects insulin sensitivity and Beta-cell function in the offspring.Journal of diabetes research · 2013Article
- Obesity induced by neonatal overfeeding worsens airway hyperresponsiveness and inflammation.PloS one · 2012Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdverse maternal environments may predispose the offspring to metabolic syndrome in adulthoods, but the underlying mechanism has not been fully understood.
methodsMaternal hyperglycemia was induced by streptozotocin (STZ) injection while control (CON) rats received citrate buffer. Litters were adjusted to eight pups per dam and then weaned to standard diet. Since 13 weeks old, a subset of offspring from STZ and CON dams were switched to high fat diet (HFD) for another 13 weeks. Glucose and insulin tolerance tests (GTT and ITT) and insulin secretion assay were performed; serum levels of lipids and leptin were measured. Hepatic fat accumulation and islet area were evaluated through haematoxylin and eosin staining.
resultsSTZ offspring exhibited lower survival rate, lower birth weights, and growth inhibition which persisted throughout the study. STZ offspring on HFD showed more severe impairment in GTT and ITT, and more profound hepatic steatosis and more severe hyperlipidemia compared with CON-HFD rats.
conclusionsOffspring from diabetic dams would be prone to exhibit low birth weight and postnatal growth inhibition, but could maintain normal glucose tolerance and insulin sensitivity. HFD accelerates development of insulin resistance in the offspring of diabetic dams mainly via a compensatory response of islets.
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