ArticleCerebrovascular diseases extra
Lower hemoglobin correlates with larger stroke volumes in acute ischemic stroke.
Article in Cerebrovascular diseases extra. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Impact of anemia on acute ischemic stroke outcomes: A systematic review of the literature.PloS one · 2023Pooled it
- Article
- Effects of anemia on short-term prognosis and imaging features of patients with acute ischemic stroke: preliminary findings.BMC neurology · 2026Article
- Sex-Difference in Stroke Outcome in Young People in Relation to Haemoglobin Level.Cerebrovascular diseases (Basel, Switzerland) · 2026Article
- Anemia and outcome of patients with ischemic stroke in a referral hospital in Cameroon.eNeurologicalSci · 2025Article
- Platelet-to-hemoglobin ratio and stroke prognosis in older adults: a nonlinear and inflammation-mediated association.Frontiers in medicine · 2025Article
- Impact of hemoglobin levels on acute ischemic stroke severity.Frontiers in neurology · 2025Article
- Exploring Relationships of Heart Rate Variability, Neurological Function, and Clinical Factors with Mortality and Behavioral Functional Outcome in Patients with Ischemic Stroke.Diagnostics (Basel, Switzerland) · 2024Article
- Association between baseline hemoglobin level and early neurological deterioration after intravenous thrombolysis in patients with acute ischemic stroke.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024Article
- Rapid triage for ischemic stroke: a machine learning-driven approach in the context of predictive, preventive and personalised medicine.The EPMA journal · 2022Article
- Characteristics and Outcomes of Intracranial Hemorrhage in Cancer Patients Visiting the Emergency Department.Journal of clinical medicine · 2022Article
- Growth Hormone and Neuronal Hemoglobin in the Brain-Roles in Neuroprotection and Neurodegenerative Diseases.Frontiers in endocrinology · 2020Review
- Reduced Ischemic Lesion Growth with Heparin in Acute Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Article
- Towards stroke prediction using electronic health records.BMC medical informatics and decision making · 2018Article
- Association of anemia and hemoglobin decrease during acute stroke treatment with infarct growth and clinical outcome.PloS one · 2018Article
- The role of additional computed tomography in the decision-making process on the secondary prevention in patients after systemic cerebral thrombolysis.Therapeutics and clinical risk management · 2016Article
- Monitoring of hematological and hemostatic parameters in neurocritical care patients.Neurocritical care · 2014Review
- Mid-term Risk Stratification of Patients with a Myocardial Infarction and Atrial Fibrillation: Beyond GRACE and CHADS.Journal of atrial fibrillation · 2013Article
- Article
- Anemia as a Predictor of Functional Disability in the Early Stage of Ischemic Stroke in a South Asian Population.Annals of Indian Academy of NeurologyArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundHemoglobin tetramers are the major oxygen-carrying molecules within the blood. We hypothesized that a lower hemoglobin level and its reduced oxygen-carrying capacity would associate with larger infarction in acute ischemic stroke patients.
methodsWe studied 135 consecutive patients with acute ischemic stroke and perfusion brain MRI. We explored the association of admission hemoglobin with initial infarct volumes on acute images and the volume of infarct expansion on follow-up images. Multivariable linear regression was performed to analyze the independent effect of hemoglobin on imaging outcomes.
resultsBivariate analyses showed a significant inverse correlation between hemoglobin and initial volume in diffusion-weighted imaging (r = -0.20, p = 0.02) and absolute infarct growth (r = -0.20, p = 0.02). Multivariable linear regression modeling revealed that hemoglobin remained independently predictive of larger infarct volumes acutely (p < 0.005) and with greater infarct expansion (p < 0.01) after adjusting for known covariates.
conclusionsHemoglobin level at the time of acute ischemic stroke associates with larger infarcts and increased infarct growth. Clarification of the mechanism of this effect may yield novel insights for therapy.
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