ArticleFrontiers in immunology2012
Autophagosomal protein dynamics and influenza virus infection.
Article in Frontiers in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Autophagy dark genes: Can we find them with machine learning?Natural sciences (Weinheim, Germany) · 2023Article
- Influence of miRNA-30a-5p on Pulmonary Fibrosis in Mice with Streptococcus pneumoniae Infection through Regulation of Autophagy by Beclin-1.BioMed research international · 2021Article
- Macrophage migration inhibitory factor enhances influenza-associated mortality in mice.JCI insight · 2019Article
- Influenza Virus Infections and Cellular Kinases.Viruses · 2019Review
- Role of c-Jun terminal kinase (JNK) activation in influenza A virus-induced autophagy and replication.Virology · 2019Article
- Immune responses in influenza A virus and human coronavirus infections: an ongoing battle between the virus and host.Current opinion in virology · 2018Review
- Autophagy in Negative-Strand RNA Virus Infection.Frontiers in microbiology · 2018Review
- Connexins: substrates and regulators of autophagy.BMC cell biology · 2016Review
- Autophagy is involved in regulating the immune response of dendritic cells to influenza A (H1N1) pdm09 infection.Immunology · 2016Article
- Broad-spectrum antiviral agents.Frontiers in microbiology · 2015Review
- Reconciling West Nile virus with the autophagic pathway.Autophagy · 2015Article
- Reserve autophagic capacity in alveolar epithelia provides a replicative niche for influenza A virus.American journal of respiratory cell and molecular biology · 2014Article
- Altered MCM protein levels and autophagic flux in aged and systemic sclerosis dermal fibroblasts.The Journal of investigative dermatology · 2014Article
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- Influenza A virus proteins NS1 and hemagglutinin along with M2 are involved in stimulation of autophagy in infected cells.Journal of virology · 2013Article
- LC3 fluorescent puncta in autophagosomes or in protein aggregates can be distinguished by FRAP analysis in living cells.Autophagy · 2013Article
- Autophagy for Better or Worse during Infectious Diseases.Frontiers in immunology · 2013Article
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Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autophagy is a constitutive, catabolic process leading to the lysosomal degradation of cytosolic proteins and organelles. However, it is also induced under stress conditions, remodeling the eukaryotic cell by regulating energy, protein, and lipid homeostasis. It is likely that the autophagosomal/lysosomal pathway evolved primordially to recycle cell components, but further functionally developed as to become part of the immune system to defend against invading pathogens. Likewise, pathogenic, foreign agents developed strategies to fight back and even to employ the autophagy machinery to their own benefit. Hence, the regulation of autophagy has many implications on human health and disease. This review summarizes the molecular dynamics of autophagosome formation, maturation, and target selection. Membrane dynamics, as well as protein-protein and protein-membrane interactions are particularly addressed. In addition, it recapitulates current knowledge of the influences of influenza virus infection on the process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.