ArticleFrontiers in immunology2012
Cross-presentation of cell-associated antigens by mouse splenic dendritic cell populations.
Article in Frontiers in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- In Situ Vaccination with Mitochondria-Targeting Immunogenic Death Inducer Elicits CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- In vitro platform establishes antigen-specific CD8Biomaterials · 2020Article
- cGAS-STING pathway in cancer biotherapy.Molecular cancer · 2020Review
- Small Molecule Enhancers of Endosome-to-Cytosol Import Augment Anti-tumor Immunity.Cell reports · 2020Article
- Cell-autonomous FLT3L shedding via ADAM10 mediates conventional dendritic cell development in mouse spleen.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- STING, DCs and the link between innate and adaptive tumor immunity.Molecular immunology · 2019Review
- Structure and function of the immune system in the spleen.Science immunology · 2019Review
- Extracellular vesicle-mediated MHC cross-dressing in immune homeostasis, transplantation, infectious diseases, and cancer.Seminars in immunopathology · 2018Review
- Dendritic Cells in the Cross Hair for the Generation of Tailored Vaccines.Frontiers in immunology · 2018Review
- The Importance of Dendritic Cells in Maintaining Immune Tolerance.Journal of immunology (Baltimore, Md. : 1950) · 2017Review
- Dendritic Cells in Systemic Lupus Erythematosus: From Pathogenic Players to Therapeutic Tools.Mediators of inflammation · 2016Review
- Loss of Phagocytic and Antigen Cross-Presenting Capacity in Aging Dendritic Cells Is Associated with Mitochondrial Dysfunction.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Quantitating MHC class II trafficking in primary dendritic cells using imaging flow cytometry.Journal of immunological methods · 2015Article
- Redirecting soluble antigen for MHC class I cross-presentation during phagocytosis.European journal of immunology · 2015Article
- Cross-Presentation of Cell-Associated Antigens by MHC Class I in Dendritic Cell Subsets.Frontiers in immunology · 2015Review
- STING-mediated DNA sensing promotes antitumor and autoimmune responses to dying cells.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Type I Interferons as Stimulators of DC-Mediated Cross-Priming: Impact on Anti-Tumor Response.Frontiers in immunology · 2013Review
- Liver-spleen axis: intersection between immunity, infections and metabolism.World journal of gastroenterology · 2013Review
- PD1-based DNA vaccine amplifies HIV-1 GAG-specific CD8+ T cells in mice.The Journal of clinical investigation · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 4 countries.
Funding
Abstract
Cross-presentation of cell-associated antigens (Ag) plays an important role in the induction of anti-tumor responses, autoimmune diseases, and transplant rejection. While several dendritic cell (DC) populations can induce pro-inflammatory CD8(+) T cell responses to cell-associated Ag during infection, in the absence of infection, cross-priming of naïve CD8(+) T cells is highly restricted. Comparison of the main splenic DC populations in mice - including the classic, cross-presenting CD8α DC and the recently described merocytic DC (mcDC) - reveals that cross-priming DCs display a distinct phenotype in cell-associated Ag uptake, endosomal/lysosomal trafficking, lysosomal acidification, and Ag persistence compared to non-cross-priming DC populations. Although the CD8α DC and mcDC subsets utilize similar processing pathways to cross-present cell-associated Ag, cross-priming by CD8α DCs is associated with IL-12 production, while the superior priming of the mcDC is critically dependent on type I IFN production. This discussion illustrates how subtle differences in internal processing pathways and their signaling sequelae significantly affect the duration of Ag cross-presentation and cytokine production by DCs, thereby shaping the ensuing CD8(+) T cell response.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.