ArticleFrontiers in immunology2012
Heterogeneity within T Cell Memory: Implications for Transplant Tolerance.
Article in Frontiers in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Activation and regulation of alloreactive T cell immunity in solid organ transplantation.Nature reviews. Nephrology · 2022Review
- Targeting inflammation and immune activation to improve CTLA4-Ig-based modulation of transplant rejection.Frontiers in immunology · 2022Review
- Aging boosts antiviral CD8+T cell memory through improved engagement of diversified recall response determinants.PLoS pathogens · 2019Article
- Selective CD28 blockade attenuates CTLA-4-dependent CD8+ memory T cell effector function and prolongs graft survival.JCI insight · 2018Article
- Potential Beneficial Effects of Cytomegalovirus Infection after Transplantation.Frontiers in immunology · 2018Review
- Murine models of transplantation tolerance through mixed chimerism: advances and roadblocks.Clinical and experimental immunology · 2017Review
- Old game, new players: Linking classical theories to new trends in transplant immunology.World journal of transplantation · 2017Review
- Memory T cells in organ transplantation: progress and challenges.Nature reviews. Nephrology · 2016Review
- T Cell Cosignaling Molecules in Transplantation.Immunity · 2016Review
- The Microbiome, Systemic Immune Function, and Allotransplantation.Clinical microbiology reviews · 2016Review
- The Evolving Roles of Memory Immune Cells in Transplantation.Transplantation · 2015Review
- Memory T Cell Migration.Frontiers in immunology · 2015Review
- Endogenous memory CD8 T cells are activated within cardiac allografts without mediating rejection.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Memory T cells in transplantation - progress and challenges.Current opinion in organ transplantation · 2013Review
- Costimulation blockade: current perspectives and implications for therapy.Transplantation · 2013Review
- Belatacept and sirolimus prolong nonhuman primate renal allograft survival without a requirement for memory T cell depletion.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2013Article
- Translating Tolerogenic Therapies to the Clinic - Where Do We Stand and What are the Barriers?Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Adaptive immunity in both mouse and man results in the generation of immunological memory. Memory T cells are both friend and foe to transplant recipients, as they are intimately involved and in many cases absolutely required for the maintenance of protective immunity in the face immunosuppression, yet from the evidence presented herein they clearly constitute a formidable barrier for the successful implementation of tolerance induction strategies in transplantation. This review describes the experimental evidence demonstrating the increased resistance of memory T cells to many distinct tolerance induction strategies, and outlines recent advances in our knowledge of the ways in which alloreactive memory T cells arise in previously untransplanted individuals. Understanding the impact of alloreactive memory T cell specificity, frequency, and quality might allow for better donor selection in order to minimize the donor-reactive memory T cell barrier in an individual transplant recipient, thus allowing stratification of relative risk of alloreactive memory T cell mediated rejection, and conversely increase the likelihood of successful establishment of tolerance. However, further research into the molecular and cellular pathways involved in alloreactive memory T cell-mediated rejection is required in order to design new strategies to overcome the memory T cell barrier, without critically impairing protective immunity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.