ArticleFrontiers in immunology2012
Regulatory T cell-mediated control of autoantibody-induced inflammation.
Article in Frontiers in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Immune regulation and cell metabolism in B cell subsets in patients with systemic lupus erythematosus.Frontiers in immunology · 2026Review
- Recombinant IgG1 Fc-μTP-L309C Ameliorates Endogenous Rheumatoid Arthritis in the K/BxN Mouse Model by Decreasing Th1 and Th17 Cells in the Spleen, Lymph Nodes and Joint and Increasing T Regulatory Cells and IL-10 in the Joint.Journal of clinical medicine · 2025Article
- The Impact of Stress on Autoimmune Disorders: Type 1 Diabetes Mellitus and Systemic Lupus Erythematosus.Cureus · 2025Review
- Regulatory T cells play a crucial role in maintaining sperm tolerance and male fertility.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Immune tolerance against infused FVIII in hemophilia A is mediated by PD-L1+ Tregs.The Journal of clinical investigation · 2022Article
- The emerging role of regulatory cell-based therapy in autoimmune disease.Frontiers in immunology · 2022Review
- Myeloid-derived suppressor cell: A crucial player in autoimmune diseases.Frontiers in immunology · 2022Review
- Profiling Serum Antibodies Against Muscle Antigens in Facioscapulohumeral Muscular Dystrophy Finds No Disease-Specific Autoantibodies.Journal of neuromuscular diseases · 2021Article
- Bispecific T-Cell Redirection versus Chimeric Antigen Receptor (CAR)-T Cells as Approaches to Kill Cancer Cells.Antibodies (Basel, Switzerland) · 2019Review
- Cytokine Networks and Survivin Peptide-Specific Cellular Immune Responses Predict Improved Survival in Patients With Glioblastoma Multiforme.EBioMedicine · 2018Article
- Regulation of the Germinal Center Response.Frontiers in immunology · 2018Review
- Immune Dysfunction and Autoimmunity as Pathological Mechanisms in Autism Spectrum Disorders.Frontiers in cellular neuroscience · 2018Review
- Phenotypic and Functional Diversities of Myeloid-Derived Suppressor Cells in Autoimmune Diseases.Mediators of inflammation · 2018Review
- Prevalence of IgG Autoantibodies against GD3 Ganglioside in Acute Zika Virus Infection.Frontiers in medicine · 2018Article
- PDGF upregulates CLEC-2 to induce T regulatory cells.Oncotarget · 2015Article
- Regulatory T cells ameliorate intrauterine growth retardation in a transgenic rat model for preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Role of myeloid-derived suppressor cells in autoimmune disease.World journal of immunology · 2014Article
- Changes of CD4(+) CD25(+) Regulatory T Cells, FoxP3 in Adjuvant Arthritis Rats with Damage of Pulmonary Function and Effects of Tripterygium Glycosides Tablet.International journal of rheumatology · 2012Article
- The molecular mechanisms of chronic inflammation development.Frontiers in immunology · 2012Article
- Regulatory T-cells and their impacts on cytokine profile of end-stage renal disease patients suffering from systemic lupus erythematosus.International journal of immunopathology and pharmacologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autoimmune inflammation including autoantibody-induced inflammation is responsible for the lethal organ damage. Autoantibody-induced inflammation can be separated in two components, autoantibody production, and local inflammatory responses. Accumulating evidence has suggested that regulatory T cells (Treg) control both antibody production and the numbers and functions of effector cells such as innate cells and T helper cells. Autoantibodies are produced by both the follicular and extrafollicular pathways. Recently, follicular regulatory T cells (T(FR)) and Qa-1 restricted CD8(+) Treg were identified as populations that are capable of suppressing follicular T helper cell (T(FH))-mediated antibody production. In local inflammation, CD4(+)CD25(+)Foxp3(+) Treg have the capacity to control inflammation by suppressing cytokine production in T helper cells. Although complement proteins contribute to autoantibody-induced local inflammation by activating innate cells, Treg including CD4(+)CD25(+)Foxp3(+) Treg are able to suppress innate cells, chiefly via IL-10 production. IL-10-secreting T cells such as T regulatory type I (Tr1) and Tr1-like cells might also play roles in the control of Th17 and innate cells. Therefore, several kinds of Tregs have the potential to control autoimmune inflammation by suppressing both autoantibody production and the local inflammatory responses induced by autoantibodies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.