ArticleFrontiers in immunology2012
Lymphoid tissue inducer cells: pivotal cells in the evolution of CD4 immunity and tolerance?
Article in Frontiers in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization.Nature reviews. Immunology · 2026Review
- Endogenous thymic regeneration: restoring T cell production following injury.Nature reviews. Immunology · 2025Review
- Innate lymphocytes: Role in alcohol-induced immune dysfunction.Frontiers in immunology · 2022Review
- Lymphoid Tissue inducer (LTi) cell ontogeny and functioning in embryo and adult.Biomedical journal · 2021Review
- Calpain in the cleavage of alpha-synuclein and the pathogenesis of Parkinson's disease.Progress in molecular biology and translational science · 2019Review
- Single-cell transcriptional analysis reveals ILC-like cells in zebrafish.Science immunology · 2018Article
- Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity.Journal of immunology (Baltimore, Md. : 1950) · 2018Review
- Brief Report: Altered Innate Lymphoid Cell Subsets in Human Lymph Node Biopsy Specimens Obtained During the At-Risk and Earliest Phases of Rheumatoid Arthritis.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- Crosstalk between Innate Lymphoid Cells and Other Immune Cells in the Tumor Microenvironment.Journal of immunology research · 2016Review
- Transcription Factor T-Bet in Atlantic Salmon: Characterization and Gene Expression in Mucosal Tissues during Aeromonas Salmonicida Infection.Frontiers in immunology · 2015Article
- Atypical MHC class II-expressing antigen-presenting cells: can anything replace a dendritic cell?Nature reviews. Immunology · 2014Review
- Fate mapping reveals origin and dynamics of lymph node follicular dendritic cells.The Journal of experimental medicine · 2014Article
- To drive or be driven: the path of a mouse model of recurrent pregnancy loss.Reproduction (Cambridge, England) · 2014Review
- Recognition strategies of group 3 innate lymphoid cells.Frontiers in immunology · 2014Review
- Innate lymphoid cells--how did we miss them?Nature reviews. Immunology · 2013Review
- Article
- Mapping of NKp46(+) Cells in Healthy Human Lymphoid and Non-Lymphoid Tissues.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
phylogeny suggests that the evolution of placentation in mammals was accompanied by substantial changes in the mammalian immune systemin particular lymph nodes and CD4 high affinity memory antibody responses co-evolved during the same period. Lymphoid tissue inducer cells (LTi) are members of an emerging family of innate lymphoid cells (ILCs) that are crucial for lymph node development, but our studies have indicated that they also play a pivotal role in the long-term maintenance of memory CD4 T cells in adult mammals through their expression of the tumor necrosis family members, OX40- and CD30-ligands. Additionally, our studies have shown that these two molecules are also key operators in CD4 effector function, as their absence obviates the need for the FoxP3 dependent regulatory T (T(regs)) cells that prevent CD4 driven autoimmune responses. In this perspective article, we summarize findings from our group over the last 10 years, and focus specifically on the role of LTi in thymus. We suggest that like memory CD4 T cells, LTi also play a role in the selection and maintenance of the T(regs) that under normal circumstances are absolutely required to regulate CD4 effector cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.