ArticleFrontiers in immunology2011
Elementary steps in T cell receptor triggering.
Article in Frontiers in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Optical sensing and control of T cell signaling pathways.Frontiers in physiology · 2023Review
- Regulating the discriminatory response to antigen by T-cell receptor.Bioscience reports · 2022Review
- Intrinsic Disorder in the T Cell Receptor Creates Cooperativity and Controls ZAP70 Binding.Biophysical journal · 2021Article
- Coordinate control of cytoskeletal remodeling and calcium mobilization during T-cell activation.Immunological reviews · 2013Review
- Co-Receptor CD8-Mediated Modulation of T-Cell Receptor Functional Sensitivity and Epitope Recognition Degeneracy.Frontiers in immunology · 2013Review
- Systems model of T cell receptor proximal signaling reveals emergent ultrasensitivity.PLoS computational biology · 2013Article
- The role of CARMA1 in T cells.Critical reviews in immunology · 2013Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanism by which antigen binding to the T cell antigen receptor (TCR) generates intracellular signaling, a process termed TCR triggering, is incompletely understood. A large body of experimental evidence has implicated multiple biophysical/biochemical effects and multiple molecules in the process of TCR triggering, which likely reflect the uniquely demanding role of the TCR in recognizing diverse antigenic ligands. In this perspective, I propose that breaking down the process of TCR triggering into tractable elementary steps may be a useful approach in building mechanistic TCR triggering models. Once these elementary steps are understood, they can be recombined to build a unified model of TCR triggering.
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