ArticleFrontiers in immunology2011
The relationship between CD27 negative and positive B cell populations in human peripheral blood.
Article in Frontiers in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed, 172 citations in OpenAlex.
- Impaired memory B-cell recall responses in the elderly following recurrent influenza vaccination.PloS one · 2021Trial
- Redemption of autoantibodies on anergic B cells by variable-region glycosylation and mutation away from self-reactivity.Proceedings of the National Academy of Sciences of the United States of America · 2014Trial
- Deciphering B cell Maturation Dynamics in Hyper-IgM Syndromes.Journal of clinical immunology · 2026Article
- The Relationship and Mechanism of CD27 with Coronary Atherosclerotic Heart Disease.Cardiovascular drugs and therapy · 2026Review
- Single-cell analysis reveals multi-faceted features of B cell development, together with age-associated B cell subpopulations.Communications biology · 2026Article
- The normal human lymph node cell classification and landscape defined by high-dimensional spatial proteomics.PloS one · 2026Article
- IgMScientific reports · 2025Article
- Machine learning approaches to dissect hybrid and vaccine-induced immunity.Communications medicine · 2025Article
- Deep profiling of B cells responding to various pathogens uncovers compartments in IgG memory B cell and antibody-secreting lineages.Science advances · 2025Article
- B Cell Receptor Repertoire Analysis of the CD21European journal of immunology · 2025Article
- Exploring the Role of Immune Cells in Glioma: Causal Associations and Clinical Implications.International journal of medical sciences · 2025Article
- An immune-focused supplemental alignment pipeline captures information missed from dominant single-cell RNA-seq analyses, including allele-specific MHC-I regulation.Frontiers in immunology · 2025Article
- Harmonisation of switched memory B cell analysis for improved CVID diagnosis and classification.Frontiers in immunology · 2025Article
- Bridging the gap: Insights in the immunopathology of Lyme borreliosis.European journal of immunology · 2024Review
- Gene profiling of Epstein-Barr Virus and human endogenous retrovirus in peripheral blood mononuclear cells of SLE patients: immune response implications.Scientific reports · 2024Article
- BCR signaling is required for posttransplant lymphoproliferative disease in immunodeficient mice receiving human B cells.Science translational medicine · 2024Article
- Article
- Mice possess a more limited natural antihuman factor VIII antibody repertoire than humans that is produced disproportionately by marginal zone B cells.Journal of thrombosis and haemostasis : JTH · 2024Article
- Characterizing infection of B cells with wild-type and vaccine strains of measles virus.iScience · 2023Article
- Inherited human ezrin deficiency impairs adaptive immunity.The Journal of allergy and clinical immunology · 2023Article
56 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD27 expression has been used to distinguish between memory and naive B cells in humans. However, low levels of mutated and isotype-switched CD27-IgD- cells are seen in healthy adults, and these are increased in some autoimmune diseases and in the elderly. Thus CD27 is not a universal marker of memory B cells in humans. Various hypotheses have been put forward as to the function of the CD27- memory population. Since we have previously found high-throughput IGHV repertoire analysis useful to distinguish "innate-like" memory B cells (CD27+IgD+), we have employed similar analyses to elucidate the relationship between CD27- and CD27+ memory B cells. IgM+IgD- memory cells in both the CD27+ and CD27- compartments share the unique characteristics of the "innate-like" IgM+IgD+CD27+ cells. The switched CD27+ and CD27- memory cells share a similar IGHV repertoire, having more in common with each other than with "innate-like" memory cells, although it is interesting that IgG2 and IgA2 subclasses of antibody in both switched memory populations have a more "innate-like" repertoire. Clonality analysis shows evidence of a close clonal relationship between the two populations in that both CD27- and CD27+ switched memory cells can be found in the same genealogical tree. The expression of CD27 does not appear to occur in a linear developmental fashion, since we see CD27- cells as precursors of CD27+ cells and vice versa. Despite the similarities, the CDR-H3 repertoire of the CD27- cells is significantly different from both the CD27+IgD+ and CD27+IgD- populations, indicating that perhaps the lack of CD27 might be related to binding properties of the Ig CDR-H3 region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.