ArticleFrontiers in immunology2011
A novel bacterial artificial chromosome-transgenic podoplanin-cre mouse targets lymphoid organ stromal cells in vivo.
Article in Frontiers in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Visualization and functional characterization of lymphoid organ fibroblasts.Immunological reviews · 2022Review
- Podoplanin regulates the migration of mesenchymal stromal cells and their interaction with platelets.Journal of cell science · 2019Article
- TLR7 Controls VSV Replication in CD169Frontiers in immunology · 2019Article
- Interferon-γ Receptor Signaling in Dendritic Cells Restrains Spontaneous Proliferation of CD4Frontiers in immunology · 2019Article
- Lymphatic Vessel Network Structure and Physiology.Comprehensive Physiology · 2018Review
- Fluorescent reporter transgenic mice for in vivo live imaging of angiogenesis and lymphangiogenesis.Angiogenesis · 2018Review
- Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity.Immunity · 2018Article
- A novel podoplanin-GFPCre mouse strain for gene deletion in lymphatic endothelial cells.Genesis (New York, N.Y. : 2000) · 2018Article
- In Vivo Gene Delivery to Lymph Node Stromal Cells Leads to Transgene-specific CD8+ T Cell Anergy in Mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2016Article
- CollagenVI-Cre mice: A new tool to target stromal cells in secondary lymphoid organs.Scientific reports · 2016Article
- Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.Nature communications · 2015Article
- Inflammation, Innate Immunity, and the Intestinal Stromal Cell Niche: Opportunities and Challenges.Frontiers in immunology · 2015Article
- Article
- Modes of Antigen Presentation by Lymph Node Stromal Cells and Their Immunological Implications.Frontiers in immunology · 2015Review
- Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses.The Journal of experimental medicine · 2014Article
- Regulation of T-cell Tolerance by Lymphatic Endothelial Cells.Journal of clinical & cellular immunology · 2014Article
- Multifunctional roles of reticular fibroblastic cells: more than meets the eye?Journal of immunology research · 2014Review
- Review
- Maturation of lymph node fibroblastic reticular cells from myofibroblastic precursors is critical for antiviral immunity.Immunity · 2013Article
- Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stromal cells provide the structural foundation of secondary lymphoid organs (SLOs), and regulate leukocyte access and cell migration within the different compartments of spleen and lymph nodes (LNs). Furthermore, several stromal cell subsets have been implied in shaping of T cell responses through direct presentation of antigen. Despite significant gain of knowledge on the biology of different SLO-resident stromal cell subsets, their molecular and functional characterization has remained incomplete. To address this need, we have generated a bacterial artificial chromosome-transgenic mouse model that utilizes the podoplanin (pdpn) promoter to express the Cre-recombinase exclusively in stromal cells of SLOs. The characterization of the Pdpn-Cre mouse revealed transgene expression in subsets of fibroblastic reticular cells and lymphatic endothelial cells in LNs. Furthermore, the transgene facilitated the identification of a novel splenic perivascular stromal cell subpopulation that forms web-like structures around central arterioles. Assessment of the in vivo antigen expression in the genetically tagged stromal cells in Pdpn-Cre mice revealed activation of both MHC I and II-restricted TCR transgenic T cells. Taken together, stromal pdpn-Cre expression is well-suited to characterize the phenotype and to dissect the function of lymphoid organ stromal cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.