ArticleFrontiers in immunology2011
A CD25⁻ positive population of activated B1 cells expresses LIFR and responds to LIF.
Article in Frontiers in immunology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- B1 Cells for Life.Immunological reviews · 2026Review
- Cold-blooded vertebrates evolved regulatory B cells to participate in inflammatory diseases.Cell communication and signaling : CCS · 2025Article
- IgMJournal of leukocyte biology · 2022Article
- Sex Influences Age-Related Changes in Natural Antibodies and CD5Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- Modulation of microbiome diversity and cytokine expression is influenced in a sex-dependent manner during aging.Frontiers in microbiomes · 2022Article
- Mast Cell Modulation of B Cell Responses: An Under-Appreciated Partnership in Host Defence.Frontiers in immunology · 2021Review
- Influenza Virus-Induced Robust Expression of SOCS3 Contributes to Excessive Production of IL-6.Frontiers in immunology · 2019Article
- Defining Natural Antibodies.Frontiers in immunology · 2017Article
- CD25Frontiers in immunology · 2017Article
- Dysregulation of peritoneal cavity B1a cells and murine primary biliary cholangitis.Oncotarget · 2016Article
- New insights into heterogeneity of peritoneal B-1a cells.Annals of the New York Academy of Sciences · 2015Review
- A novel mechanism of B cell-mediated immune suppression through CD73 expression and adenosine production.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Human B-1 cells take the stage.Annals of the New York Academy of Sciences · 2013Review
- Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Induction of Th17 cell differentiation by B-1 cells.Frontiers in immunology · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
B1 B cells defend against infectious microorganisms by spontaneous secretion of broadly reactive "natural" immunoglobulin that appears in the absence of immunization. Among many distinguishing characteristics, B1 B cells display evidence of activation that includes phosphorylated STAT3. In order to identify the origin of pSTAT3 we examined interleukin-2 receptor (IL-2R) expression on B1 cells. We found that some (about 1/5) B1a cells express the IL-2R α chain, CD25. Although lacking CD122 and unresponsive to IL-2, B1a cells marked by CD25 express increased levels of activated signaling intermediates, interruption of which results in diminished CD25. Further, CD25⁺ B1a cells contain most of the pSTAT3 found in the B1a population as a whole. Moreover, CD25⁺ B1a cells express leukemia inhibitory factor receptor (LIFR), and respond to LIF by upregulating pSTAT3. Together, these results define a new subset of B1a cells that is marked by activation-dependent CD25 expression, expresses substantial amounts of activated STAT3, and contains a functional LIFR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.