ArticleProceedings of the National Academy of Sciences of the United States of America2012
Spatial-temporal dynamics of collective chemosensing.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Nematic cell alignment directs calcium waves in an epithelial monolayer.Biophysical journal · 2026Article
- Quantifying Information Exchange Between Cells in Inflammaging.Bioengineering (Basel, Switzerland) · 2026Article
- Nematic cell alignment directs calcium waves.bioRxiv : the preprint server for biology · 2025Article
- Formation of recurring transient CaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Emergence of synchronized multicellular mechanosensing from spatiotemporal integration of heterogeneous single-cell information transfer.Cell systems · 2022Article
- Temporal signals drive the emergence of multicellular information networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction.Frontiers in cell and developmental biology · 2022Review
- Article
- Phase synchronization of fluid-fluid interfaces as hydrodynamically coupled oscillators.Nature communications · 2020Article
- A Fluidic Culture Platform for Spatially Patterned Cell Growth, Differentiation, and Cocultures.Tissue engineering. Part A · 2018Article
- Collective gradient sensing and chemotaxis: modeling and recent developments.Journal of physics. Condensed matter : an Institute of Physics journal · 2018Review
- Wound-induced CaMolecular biology of the cell · 2017Article
- Dynamic Sampling and Information Encoding in Biochemical Networks.Biophysical journal · 2017Article
- Probing three-dimensional collective cancer invasion with DIGME.Cancer convergence · 2017Article
- Communication shapes sensory response in multicellular networks.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Cellular Architecture Regulates Collective Calcium Signaling and Cell Contractility.PLoS computational biology · 2016Article
- Mechanics regulates ATP-stimulated collective calcium response in fibroblast cells.Journal of the Royal Society, Interface · 2015Article
- Propagating waves of directionality and coordination orchestrate collective cell migration.PLoS computational biology · 2014Article
- Probing cell-cell communication with microfluidic devices.Lab on a chip · 2013Review
- Mechanically induced intercellular calcium communication in confined endothelial structures.Biomaterials · 2013Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Although the process of chemosensing by individual cells is intrisically stochastic, multicellular organisms exhibit highly regulated responses to external stimulations. Two key elements to understand the deterministic features of chemosensing are intercellular communications and the role of pacemaker cells. To characterize the collective behavior induced by these two factors, we study the spatial-temporal calcium dynamics of fibroblast cells in response to ATP stimulation. We find that closely packed cell colonies exhibit faster, more synchronized, and highly correlated responses compared to isolated cells. In addition, we demonstrate for chemosensing the existence of pacemaker cells and how the presence of gap junctions impact the first step of the collective response. By further comparing these results with the calcium dynamics of cells embedded in thin hydrogel films, where intercellular communication is only possible via diffusing molecules, we conclude that gap junctions are required for synchronized and highly correlated responses among cells in high density colonies. In addition, in high density cell colonies, both communication channels lead to calcium oscillations following the stimulation by external ATP. While the calcium oscillations associated with cells directly exposed to external flows were transient, the oscillations of hydrogel trapped cells can persist with a fundamental frequency and higher harmonics. Our observations and measurements highlight the crucial role of intercellular signaling for generating regulated spatial and temporal dynamics in cell colonies and tissues.
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