ArticleProceedings of the National Academy of Sciences of the United States of America2012
Generic temperature compensation of biological clocks by autonomous regulation of catalyst concentration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed.
- Low temperature abolishes human cellular circadian rhythm through Hopf bifurcation.NPJ systems biology and applications · 2025Article
- When lowering temperature, the in vivo circadian clock in cyanobacteria follows and surpasses the in vitro protein clock trough the Hopf bifurcation.Scientific reports · 2025Article
- A Compensated Clock: Temperature and Nutritional Compensation Mechanisms Across Circadian Systems.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Temperature compensation through kinetic regulation in biochemical oscillators.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Determining subunit-subunit interaction from statistics of cryo-EM images: observation of nearest-neighbor coupling in a circadian clock protein complex.Nature communications · 2023Article
- Systematic analysis of negative and positive feedback loops for robustness and temperature compensation in circadian rhythms.NPJ systems biology and applications · 2023Article
- A linear reciprocal relationship between robustness and plasticity in homeostatic biological networks.PloS one · 2023Article
- Role of the reaction-structure coupling in temperature compensation of the KaiABC circadian rhythm.PLoS computational biology · 2022Article
- Elucidation of master allostery essential for circadian clock oscillation in cyanobacteria.Science advances · 2022Article
- Symmetry breaking meets multisite modification.eLife · 2021Article
- Mechanism of autonomous synchronization of the circadian KaiABC rhythm.Scientific reports · 2021Article
- Bayesian modeling reveals metabolite-dependent ultrasensitivity in the cyanobacterial circadian clock.Molecular systems biology · 2020Article
- Single-molecular and ensemble-level oscillations of cyanobacterial circadian clock.Biophysics and physicobiology · 2018Article
- Role of ATP Hydrolysis in Cyanobacterial Circadian Oscillator.Scientific reports · 2017Article
- Period Robustness and Entrainability of the Kai System to Changing Nucleotide Concentrations.Biophysical journal · 2017Article
- Low temperature nullifies the circadian clock in cyanobacteria through Hopf bifurcation.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Robust network topologies for generating oscillations with temperature-independent periods.PloS one · 2017Article
- Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock.Frontiers in neurology · 2017Review
- Boosting functionality of synthetic DNA circuits with tailored deactivation.Nature communications · 2016Article
- High-resolution mapping of bifurcations in nonlinear biochemical circuits.Nature chemistry · 2016Article
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2 authors.
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Abstract
Circadian clocks--ubiquitous in life forms ranging from bacteria to multicellular organisms--often exhibit intrinsic temperature compensation; the period of circadian oscillators is maintained constant over a range of physiological temperatures, despite the expected Arrhenius form for the reaction coefficient. Observations have shown that the amplitude of the oscillation depends on the temperature but the period does not; this suggests that although not every reaction step is temperature independent, the total system comprising several reactions still exhibits compensation. Here we present a general mechanism for such temperature compensation. Consider a system with multiple activation energy barriers for reactions, with a common enzyme shared across several reaction steps. The steps with the highest activation energy rate-limit the cycle when the temperature is not high. If the total abundance of the enzyme is limited, the amount of free enzyme available to catalyze a specific reaction decreases as more substrates bind to the common enzyme. We show that this change in free enzyme abundance compensates for the Arrhenius-type temperature dependence of the reaction coefficient. Taking the example of circadian clocks with cyanobacterial proteins KaiABC, consisting of several phosphorylation sites, we show that this temperature compensation mechanism is indeed valid. Specifically, if the activation energy for phosphorylation is larger than that for dephosphorylation, competition for KaiA shared among the phosphorylation reactions leads to temperature compensation. Moreover, taking a simpler model, we demonstrate the generality of the proposed compensation mechanism, suggesting relevance not only to circadian clocks but to other (bio)chemical oscillators as well.
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